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pcdh7b protocadherin 7b [ Danio rerio (zebrafish) ]

Gene ID: 555504, updated on 12-Sep-2024

Summary

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Official Symbol
pcdh7bprovided by ZNC
Official Full Name
protocadherin 7bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-299
See related
Ensembl:ENSDARG00000060610 AllianceGenome:ZFIN:ZDB-GENE-081104-299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu592; si:dkey-104n16.1
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including epidermis; nervous system; neural plate; otic vesicle; and periderm. Orthologous to human PCDH7 (protocadherin 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See pcdh7b in Genome Data Viewer
Location:
chromosome: 7
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (63325026..63574577)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (63014856..63148221)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene stromal interaction molecule 2b Neighboring gene uncharacterized LOC103908683 Neighboring gene si:ch211-208g1.1 Neighboring gene uncharacterized LOC101886703

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential expression, alternative splicing, and adhesive properties of the zebrafish δ1-protocadherins. Blevins CJ, et al. Neuroscience, 2011 Dec 29. PMID 22001682
  2. Loss of slc39a14 causes simultaneous manganese hypersensitivity and deficiency in zebrafish. Tuschl K, et al. Dis Model Mech, 2022 Jun 1. PMID 35514229, Free PMC Article
  3. Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Lüffe TM, et al. Transl Psychiatry, 2021 Oct 14. PMID 34650032, Free PMC Article
  4. Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1. Kimelman D, et al. Elife, 2017 Dec 28. PMID 29283341, Free PMC Article
  5. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Hogl S, et al. Proteomics, 2013 May. PMID 23457027

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin-7b
Names
novel protocadherin protein
protocadherin 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365653.1 → NP_001352582.1  protocadherin-7b

    Status: VALIDATED

    Source sequence(s)
    BX901964, CR318596
    UniProtKB/TrEMBL
    A0A0H2UKU4, A0A8N7TCQ2
    Related
    ENSDARP00000139416.1, ENSDART00000161436.2
    Conserved Domains (2) summary
    cd11304
    Location:512 → 606
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:813 → 1022
    Protocadherin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    63325026..63574577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478010.2 → XP_021333685.1  protocadherin-7b isoform X1

    UniProtKB/TrEMBL
    A0A8M9QI41
    Conserved Domains (2) summary
    cd11304
    Location:512 → 606
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:813 → 1022
    Protocadherin

  2. XM_068222304.1 → XP_068078405.1  protocadherin-7b isoform X2

  3. XM_021478012.2 → XP_021333687.1  protocadherin-7b isoform X5

    UniProtKB/TrEMBL
    A0A8M9PQ84
    Conserved Domains (3) summary
    cd11304
    Location:512 → 606
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:813 → 1022
    Protocadherin
    cl09101
    Location:29 → 90
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

  4. XM_021478011.2 → XP_021333686.1  protocadherin-7b isoform X3

    UniProtKB/TrEMBL
    A0A8M9QD52
    Related
    ENSDARP00000080047.5, ENSDART00000085612.6
    Conserved Domains (3) summary
    cd11304
    Location:512 → 606
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:813 → 1022
    Protocadherin
    cl09101
    Location:29 → 90
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

  5. XM_005166497.5 → XP_005166554.1  protocadherin-7b isoform X4

    UniProtKB/TrEMBL
    A0A8M2BE32, X1WEN8
    Related
    ENSDARP00000128689.1, ENSDART00000147785.3
    Conserved Domains (3) summary
    cd11304
    Location:512 → 606
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08374
    Location:813 → 1024
    Protocadherin; Protocadherin
    cl09101
    Location:29 → 98
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus
Nucleotide Protein Strain
Heading Accession and Version

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