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PRH2 proline rich protein HaeIII subfamily 2 [ Homo sapiens (human) ]

Gene ID: 5555, updated on 11-Apr-2024

Summary

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Official Symbol
PRH2provided by HGNC
Official Full Name
proline rich protein HaeIII subfamily 2provided by HGNC
Primary source
HGNC:HGNC:9367
See related
Ensembl:ENSG00000134551 MIM:168790; AllianceGenome:HGNC:9367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pr; pr1/Pr2; PRP-1/PRP-2
Summary
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]
Expression
Restricted expression toward salivary gland (RPKM 6639.8) See more
Orthologs
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Genomic context

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See PRH2 in Genome Data Viewer
Location:
12p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10929236..10934845)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10782594..10807884)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11081835..11087444)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene Sharpr-MPRA regulatory region 13514 Neighboring gene taste 2 receptor member 12 pseudogene Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene taste 2 receptor member 13 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:11094509-11095708 Neighboring gene taste 2 receptor member 14 Neighboring gene taste 2 receptor member 15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel Ser O-glucuronidation in acidic proline-rich proteins identified by tandem mass spectrometry. Jonsson AP, et al. FEBS Lett, 2000 Jun 16. PMID 10858503
  2. A frequent mutation in the acidic proline-rich protein gene, PRH2, causing a Q147K change closely adjacent to the bacterial binding domain of the cognate salivary PRP (Pr1') in Afro-Americans. Mutations in brief no. 154. Online. Azen EA. Hum Mutat, 1998. PMID 10627138
  3. The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation to a salivary proline-rich phosphoprotein, protein C. Isemura S, et al. J Biochem, 1980 Apr. PMID 7390979
  4. The primary structure of a salivary calcium-binding proline-rich phosphoprotein (protein C), a possible precursor of a related salivary protein A. Wong RS, et al. J Biol Chem, 1980 Jun 25. PMID 7380845
  5. Primary structure of the active tryptic fragments of human and monkey salivary anionic proline-rich proteins. Schlesinger DH, et al. Int J Pept Protein Res, 1981 Jan. PMID 7228490

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries.
    Title: Human PRH1, PRH2 susceptibility and resistance and Streptococcus mutans virulence phenotypes specify different microbial profiles in caries.
  2. We investigated whether PRH1 and PRH2 polymorphisms in saliva acidic proline-rich protein (PRP) receptors for indigenous bacteria match and predict individual differences in the development of caries..They instead developed 3.9-fold more caries than P1 children from plaque accumulation in general when treated with orthodontic multibrackets; and had basic PRP polymorphisms and low DMBT1-mediated S. mutans adhesion
    Title: Genetic- and Lifestyle-dependent Dental Caries Defined by the Acidic Proline-rich Protein Genes PRH1 and PRH2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686B01256, DKFZp686F14256, DKFZp686I11251, DKFZp686J06255, DKFZp686L01253, DKFZp686L16244, DKFZp686M04243, DKFZp686N24248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
salivary acidic proline-rich phosphoprotein 1/2
Names
acidic salivary proline-rich protein, HaeIII type, 2
parotid acidic protein
parotid double-band protein
parotid proline-rich protein 1/2
protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110213.1 → NP_001103683.1  salivary acidic proline-rich phosphoprotein 1/2 preproprotein

    See identical proteins and their annotated locations for NP_001103683.1

    Status: REVIEWED

    Source sequence(s)
    AC006518, BC095488, BX648656
    Consensus CDS
    CCDS8636.1
    UniProtKB/Swiss-Prot
    A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6
    Related
    ENSP00000379682.3, ENST00000396400.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10929236..10934845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429101.1 → XP_047285057.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

    UniProtKB/Swiss-Prot
    A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6
    Related
    ENSP00000371271.3, ENST00000381847.7

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    108262..133551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329620.1 → XP_054185595.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

    UniProtKB/Swiss-Prot
    A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

  2. XM_054329621.1 → XP_054185596.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

    UniProtKB/Swiss-Prot
    A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    108262..133551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329988.1 → XP_054185963.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

    UniProtKB/Swiss-Prot
    A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

  2. XM_054329989.1 → XP_054185964.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

    UniProtKB/Swiss-Prot
    A2VCM0, A3KN66, A5D902, B2RMW2, P02810, Q4VBP2, Q53XA2, Q6P2F6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10782594..10807884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372462.1 → XP_054228437.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

  2. XM_054372463.1 → XP_054228438.1  salivary acidic proline-rich phosphoprotein 1/2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005042.4: Suppressed sequence

    Description
    NM_005042.4: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02810.3 GenPept UniProtKB/Swiss-Prot:P02810

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