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actr2b actin related protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 554861, updated on 12-Sep-2024

Summary

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Official Symbol
actr2bprovided by ZNC
Official Full Name
actin related protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050410-4
See related
Ensembl:ENSDARG00000070076 AllianceGenome:ZFIN:ZDB-GENE-050410-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
actr2; zgc:110550
Summary
Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Acts upstream of or within primitive erythrocyte differentiation. Predicted to be located in cytoplasm; nucleus; and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Orthologous to human ACTR2 (actin related protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See actr2b in Genome Data Viewer
Location:
chromosome: 13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (5946572..5978433, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (5818130..5849978, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene Meis homeobox 1 b Neighboring gene sprouty related EVH1 domain containing 2b Neighboring gene PHD finger protein 10 Neighboring gene deltaD

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC110550, MGC174305

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within primitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of double-strand break repair via nonhomologous end joining ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Arp2/3 protein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
actin-related protein 2-B
Names
ARP2 actin related protein 2b homolog
ARP2 actin-related protein 2
actin-like protein 2-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017542.2 → NP_001017542.1  actin-related protein 2-B

    Status: PROVISIONAL

    Source sequence(s)
    BC092187
    UniProtKB/Swiss-Prot
    Q56A35
    Related
    ENSDARP00000093331.4, ENSDART00000102555.6
    Conserved Domains (2) summary
    smart00268
    Location:6 → 388
    ACTIN; Actin
    cl17037
    Location:1 → 382
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    5946572..5978433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169510.5 → XP_005169567.1  actin-related protein 2-B isoform X2

    UniProtKB/Swiss-Prot
    Q56A35
    Conserved Domains (2) summary
    smart00268
    Location:6 → 388
    ACTIN; Actin
    cl17037
    Location:1 → 382
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_021480582.2 → XP_021336257.1  actin-related protein 2-B isoform X1

    UniProtKB/TrEMBL
    A0A8M9PXU6
    Conserved Domains (1) summary
    smart00268
    Location:6 → 393
    ACTIN; Actin

RNA

  1. XR_002459806.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56A35.1 GenPept UniProtKB/Swiss-Prot:Q56A35

Gene LinkOut

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