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DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 [ Homo sapiens (human) ]

Gene ID: 55466, updated on 7-Apr-2024

Summary

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Official Symbol
DNAJA4provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member A4provided by HGNC
Primary source
HGNC:HGNC:14885
See related
Ensembl:ENSG00000140403 AllianceGenome:HGNC:14885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST104; MSTP104; PRO1472
Summary
Enables chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 43.9), testis (RPKM 33.4) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
15q25.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (78264145..78282191)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (76126705..76144763)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78556487..78574533)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9911 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78500283-78500794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9913 Neighboring gene DNAJA4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6709 Neighboring gene uncharacterized LOC105370910 Neighboring gene Sharpr-MPRA regulatory region 12554 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:78580466-78580710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:78591149-78592116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:78592117-78593083 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78611709-78612294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78614637-78615220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78623995-78624809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78632245-78632873 Neighboring gene cellular retinoic acid binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus. Liu Z, et al. Genes (Basel), 2022 Dec 24. PMID 36672799, Free PMC Article
  2. DNA methylation status of DNAJA4 is essential for human erythropoiesis. Zhang H, et al. Epigenomics, 2022 Oct. PMID 36420716
  3. DnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells. Liu RJ, et al. Chin Med J (Engl), 2020 Sep 9. PMID 32925288, Free PMC Article
  4. DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes. Sun YZ, et al. J Dermatol Sci, 2018 Sep. PMID 29807809
  5. Hsp40 chaperones promote degradation of the HERG potassium channel. Walker VE, et al. J Biol Chem, 2010 Jan 29. PMID 19940115, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.
    Title: DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.
  2. DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus.
    Title: DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus.
  3. DNA methylation status of DNAJA4 is essential for human erythropoiesis.
    Title: DNA methylation status of DNAJA4 is essential for human erythropoiesis.
  4. DnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells.
    Title: DnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells.
  5. Hyperthermia reduced HaCaT cell proliferation and promoted cytokine expressions responsible for anti-viral activity, mainly through a NF-kB dependent pathway. DNAJA4-deficiency enhanced the activation of NF-kB by hyperthermia in HaCaT cells.
    Title: DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inclusion body assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dnaJ homolog subfamily A member 4
Names
DnaJ (Hsp40) homolog, subfamily A, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130182.2 → NP_001123654.1  dnaJ homolog subfamily A member 4 isoform 2

    See identical proteins and their annotated locations for NP_001123654.1

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Consensus CDS
    CCDS45316.1
    UniProtKB/Swiss-Prot
    E9PDM9, Q6AW87, Q8N5Z4, Q8N7P2, Q8WW22
    Related
    ENSP00000378321.3, ENST00000394852.8
    Conserved Domains (1) summary
    PTZ00037
    Location:2 → 394
    PTZ00037; DnaJ_C chaperone protein; Provisional

  2. NM_001130183.2 → NP_001123655.1  dnaJ homolog subfamily A member 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090607, AK096616, AL133096, BC031044, DA561365
    Consensus CDS
    CCDS45317.1
    UniProtKB/Swiss-Prot
    Q8WW22
    UniProtKB/TrEMBL
    Q69YX3
    Related
    ENSP00000413499.2, ENST00000446172.2
    Conserved Domains (4) summary
    PRK14277
    Location:7 → 354
    PRK14277; chaperone protein DnaJ; Provisional
    cd10719
    Location:108 → 174
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:79 → 305
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl02542
    Location:9 → 38
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

  3. NM_001387384.1 → NP_001374313.1  dnaJ homolog subfamily A member 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Conserved Domains (1) summary
    PTZ00037
    Location:2 → 412
    PTZ00037; DnaJ_C chaperone protein; Provisional

  4. NM_001387385.1 → NP_001374314.1  dnaJ homolog subfamily A member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Consensus CDS
    CCDS45316.1
    UniProtKB/Swiss-Prot
    E9PDM9, Q6AW87, Q8N5Z4, Q8N7P2, Q8WW22
    Conserved Domains (1) summary
    PTZ00037
    Location:2 → 394
    PTZ00037; DnaJ_C chaperone protein; Provisional

  5. NM_001387386.1 → NP_001374315.1  dnaJ homolog subfamily A member 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Conserved Domains (1) summary
    PTZ00037
    Location:2 → 317
    PTZ00037; DnaJ_C chaperone protein; Provisional

  6. NM_001387387.1 → NP_001374316.1  dnaJ homolog subfamily A member 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Conserved Domains (2) summary
    COG0484
    Location:2 → 110
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl21722
    Location:106 → 144
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

  7. NM_001387388.1 → NP_001374317.1  dnaJ homolog subfamily A member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090607
    Consensus CDS
    CCDS45316.1
    UniProtKB/Swiss-Prot
    E9PDM9, Q6AW87, Q8N5Z4, Q8N7P2, Q8WW22
    Related
    ENSP00000339581.3, ENST00000343789.7
    Conserved Domains (1) summary
    PTZ00037
    Location:2 → 394
    PTZ00037; DnaJ_C chaperone protein; Provisional

  8. NM_018602.4 → NP_061072.3  dnaJ homolog subfamily A member 4 isoform 1

    See identical proteins and their annotated locations for NP_061072.3

    Status: VALIDATED

    Source sequence(s)
    AC090607, AK096616, AL133096, BC021720, DB047940
    Consensus CDS
    CCDS10299.2
    UniProtKB/Swiss-Prot
    Q8WW22
    UniProtKB/TrEMBL
    Q69YX3
    Related
    ENSP00000378324.3, ENST00000394855.7
    Conserved Domains (4) summary
    cd10719
    Location:164 → 230
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:135 → 361
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    PTZ00037
    Location:15 → 423
    PTZ00037; DnaJ_C chaperone protein; Provisional
    pfam00226
    Location:36 → 94
    DnaJ; DnaJ domain

RNA

  1. NR_170653.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

  2. NR_170654.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

  3. NR_170655.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

  4. NR_170656.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

  5. NR_170657.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

  6. NR_170658.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

  7. NR_170666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090607

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    78264145..78282191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432836.1 → XP_047288792.1  dnaJ homolog subfamily A member 4 isoform X2

  2. XM_047432834.1 → XP_047288790.1  dnaJ homolog subfamily A member 4 isoform X1

  3. XM_047432835.1 → XP_047288791.1  dnaJ homolog subfamily A member 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    76126705..76144763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378417.1 → XP_054234392.1  dnaJ homolog subfamily A member 4 isoform X2

  2. XM_054378416.1 → XP_054234391.1  dnaJ homolog subfamily A member 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WW22.1 GenPept UniProtKB/Swiss-Prot:Q8WW22

Gene LinkOut

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