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JPX JPX transcript, XIST activator [ Homo sapiens (human) ]

Gene ID: 554203, updated on 28-Oct-2024

Summary

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Official Symbol
JPXprovided by HGNC
Official Full Name
JPX transcript, XIST activatorprovided by HGNC
Primary source
HGNC:HGNC:37191
See related
Ensembl:ENSG00000225470 MIM:300832; AllianceGenome:HGNC:37191
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENOX; DCBALD06; LINC00183; NCRNA00183
Summary
JPX is a nonprotein-coding RNA transcribed from a gene within the X-inactivation center (XIC; MIM 314670) that appears to participate in X chromosome inactivation (Tian et al., 2010 [PubMed 21029862]).[supplied by OMIM, Feb 2011]
Expression
Ubiquitous expression in fat (RPKM 1.9), thyroid (RPKM 1.8) and 25 other tissues See more
Orthologs
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Genomic context

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See JPX in Genome Data Viewer
Location:
Xq13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (73944324..74070384)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (72377875..72503933)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (73164159..73290219)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TSIX transcript, XIST antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29763 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:73071267-73071768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:73083465-73084112 Neighboring gene X inactive specific transcript Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:73134838-73135338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29765 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:73185196-73185760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:73186327-73186890 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:73197425-73197984 Neighboring gene ribosomal protein SA pseudogene 14 Neighboring gene FTX transcript, XIST regulator Neighboring gene SHISA5 pseudogene 2 Neighboring gene AARSD1 pseudogene 1 Neighboring gene ubiquitin like with PHD and ring finger domains 2 pseudogene 1 Neighboring gene DEAD-box helicase 3 pseudogene 1 Neighboring gene DEAD-box helicase 3 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers. Wang Y, et al. Chin Med J (Engl), 2023 Apr 5. PMID 37027401, Free PMC Article
  2. Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells. Li XD, et al. Cancer Sci, 2021 Nov. PMID 34390075, Free PMC Article
  3. LncRNA JPX regulates proliferation and apoptosis of nucleus pulposus cells by targeting the miR-18a-5p/HIF-1α/Hippo-YAP pathway. Yang H, et al. Biochem Biophys Res Commun, 2021 Aug 20. PMID 34111667
  4. LncRNA JPX overexpressed in oral squamous cell carcinoma drives malignancy via miR-944/CDH2 axis. Yao Y, et al. Oral Dis, 2021 May. PMID 32881231
  5. Long noncoding RNA-JPX predicts the poor prognosis of ovarian cancer patients and promotes tumor cell proliferation, invasion and migration by the PI3K/Akt/mTOR signaling pathway. Li J, et al. Eur Rev Med Pharmacol Sci, 2018 Dec. PMID 30556851

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.
    Title: lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma.
  2. Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers.
    Title: Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers.
  3. The beta-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance.
    Title: The β-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance.
  4. LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis via targeting the miR-378g/CCL5 axis.
    Title: LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis via targeting the miR-378g/CCL5 axis.
  5. Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer.
    Title: Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer.
  6. Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells.
    Title: Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells.
  7. LncRNA JPX regulates proliferation and apoptosis of nucleus pulposus cells by targeting the miR-18a-5p/HIF-1alpha/Hippo-YAP pathway.
    Title: LncRNA JPX regulates proliferation and apoptosis of nucleus pulposus cells by targeting the miR-18a-5p/HIF-1α/Hippo-YAP pathway.
  8. LncRNA JPX overexpressed in oral squamous cell carcinoma drives malignancy via miR-944/CDH2 axis.
    Title: LncRNA JPX overexpressed in oral squamous cell carcinoma drives malignancy via miR-944/CDH2 axis.
  9. Long noncoding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR197.
    Title: Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197.
  10. Long non-coding RNA JPX correlates with poor prognosis and tumor progression in non-small-cell lung cancer by interacting with miR-145-5p and CCND2.
    Title: Long non-coding RNA JPX correlates with poor prognosis and tumor progression in non-small-cell lung cancer by interacting with miR-145-5p and CCND2.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • JPX transcript, XIST activator (non-protein coding)
  • expressed neighbor of XIST
  • just proximal to XIST

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of chromatin loopin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024582.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL139400, AL627389, BC071776, BP871721
    Related
    ENST00000602772.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    73944324..74070384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    72377875..72503933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials