ctss2.1 cathepsin S, ortholog2, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ctss2.1provided by ZNC
Official Full Name: cathepsin S, ortholog2, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-559
See related: Ensembl:ENSDARG00000074656 AllianceGenome:ZFIN:ZDB-GENE-050522-559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ctssb1; zf-a41; ctssb.1; fc38f10; fc47h06; ns:zf-a41; im:6797184; wu:fc38f10; wu:fc47h06; wu:fi17f10; zgc:112226; zgc:112369; zgc:123302
Summary: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region and phagocytic vesicle. Predicted to be active in extracellular space and lysosome. Is expressed in cardiac ventricle. Human ortholog(s) of this gene implicated in neuropathy. Orthologous to human CTSS (cathepsin S). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (29509127..29513434)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (29574504..29578811)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc47h06 (e-PCR)
- UniSTS:189217

AA549805 (e-PCR)
- UniSTS:206915

AI667284 (e-PCR)
- UniSTS:206067

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cathepsin S, ortholog2, tandem duplicate 1

Names: cathepsin S, b.1; cathepsin Sb, tandem duplicate 1

NP_001019580.2

EC 3.4.22.27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024409.2 → NP_001019580.2 cathepsin S, ortholog2, tandem duplicate 1 precursor

See identical proteins and their annotated locations for NP_001019580.2

Status: VALIDATED

Source sequence(s)

AL954306, BC095788, BI980010, EH449466

UniProtKB/TrEMBL

Q3B7H0, Q502A6

Related

ENSDARP00000099159.3, ENSDART00000112116.4

Conserved Domains (3) summary

PTZ00203
Location:6 → 324

PTZ00203; cathepsin L protease; Provisional

smart00848
Location:27 → 86

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:115 → 329

Peptidase_C1; Papain family cysteine protease