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gins2 GINS complex subunit 2 [ Danio rerio (zebrafish) ]

Gene ID: 554146, updated on 2-Nov-2024

Summary

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Official Symbol
gins2provided by ZNC
Official Full Name
GINS complex subunit 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050419-19
See related
Ensembl:ENSDARG00000002304 AllianceGenome:ZFIN:ZDB-GENE-050419-19
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:112262; si:dkey-265o13.3
Summary
Predicted to be involved in double-strand break repair via break-induced replication. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleus. Predicted to be part of GINS complex. Is expressed in ciliary marginal zone and optic tectum. Orthologous to human GINS2 (GINS complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gins2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (30481030..30499456, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (30502776..30521202, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101883985 Neighboring gene Gse1 coiled-coil protein b Neighboring gene uncharacterized LOC137488295 Neighboring gene cytochrome c oxidase subunit 4I1 Neighboring gene ER membrane protein complex subunit 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tissue-Specific Requirement for the GINS Complex During Zebrafish Development. Varga M, et al. Front Cell Dev Biol, 2020. PMID 32548116, Free PMC Article
  2. Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. Cerveny KL, et al. MicroPubl Biol, 2021. PMID 34723143, Free PMC Article
  3. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Yang Y, et al. Mol Cell, 2019 Sep 19. PMID 31399345
  4. Genomic responses of DNA methylation and transcript profiles in zebrafish cells upon nutrient deprivation stress. Fan X, et al. Sci Total Environ, 2020 Jun 20. PMID 32208287
  5. Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Hou J, et al. Environ Sci Technol, 2018 Jul 17. PMID 29944347

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA replication complex GINS protein PSF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024439.1 → NP_001019610.1  DNA replication complex GINS protein PSF2

    See identical proteins and their annotated locations for NP_001019610.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095711
    UniProtKB/TrEMBL
    A0A8M1N6W9, Q4VBJ6
    Related
    ENSDARP00000035433.6, ENSDART00000033746.7
    Conserved Domains (2) summary
    cd11712
    Location:55 → 174
    GINS_A_psf2; Alpha-helical domain of GINS complex protein Psf2 (partner of Sld5 2)
    cd21694
    Location:2 → 63
    GINS_B_Psf2; beta-strand (B) domain of GINS complex protein Psf2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    30481030..30499456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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