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smim8 small integral membrane protein 8 [ Danio rerio (zebrafish) ]

Gene ID: 554139, updated on 12-Sep-2024

Summary

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Official Symbol
smim8provided by ZNC
Official Full Name
small integral membrane protein 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-423
See related
Ensembl:ENSDARG00000071040 AllianceGenome:ZFIN:ZDB-GENE-050522-423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj99f07; wu:fj99f07; zgc:112287; zgc:136361; si:busm1-189a20.6; si:ch211-241j12.5
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SMIM8 (small integral membrane protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See smim8 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (186277..188723, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (197642..200088, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-241j12.3 Neighboring gene ribosome production factor 2 homolog Neighboring gene si:ch211-241j12.4 Neighboring gene gap junction protein beta 7 Neighboring gene zinc finger protein 292b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC136361

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small integral membrane protein 8
Names
UPF0708 protein C6orf162 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024433.3 → NP_001019604.2  small integral membrane protein 8 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BX511077, EH483646, EH552657
    UniProtKB/Swiss-Prot
    Q502E5, Q5RHI7, Q5SNV3
    UniProtKB/TrEMBL
    A0A8M1N6Q9, F1QLE8
    Related
    ENSDARP00000095554.2, ENSDART00000104784.4
    Conserved Domains (1) summary
    pfam14937
    Location:24 → 103
    DUF4500; Domain of unknown function (DUF4500)

  2. NM_001271743.1 → NP_001258672.1  small integral membrane protein 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BX511077, EH445683, EH483646, EH552657
    UniProtKB/TrEMBL
    A0A8M1P3V4, F1R496
    Related
    ENSDARP00000119704.2, ENSDART00000135530.3
    Conserved Domains (1) summary
    pfam14937
    Location:24 → 52
    DUF4500; Domain of unknown function (DUF4500)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    186277..188723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q502E5.1 GenPept UniProtKB/Swiss-Prot:Q502E5

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