fabp1b.1 fatty acid binding protein 1b, tandem duplicate 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fabp1b.1provided by ZNC
Official Full Name: fatty acid binding protein 1b, tandem duplicate 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-96
See related: Ensembl:ENSDARG00000059227 AllianceGenome:ZFIN:ZDB-GENE-050522-96
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fabp1b; Zf-FABP1b; zgc:110431
Summary: Predicted to enable fatty acid binding activity. Acts upstream of or within response to lipid. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in gill; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human FABP1 (fatty acid binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 8

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (999452..1006174)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (933709..940431)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential regulation of the duplicated fabp1b promoters may be the result of peroxisome proliferator-activated receptors loss in fabp1b.2 during a meiotic crossing-over event.
Title: Divergent evolution of cis-acting peroxisome proliferator-activated receptor elements that differentially control the tandemly duplicated fatty acid-binding protein genes, fabp1b.1 and fabp1b.2, in zebrafish.
In vivo experiments demonstrated, for the first time, that intestinal absorption of dietary BODIPY-FLC(12) was followed by colocalization of the labeled FA with Fabp1b and Fabp2 in the nuclei.
Title: Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei.
Data suggest that the duplicated fabp1b genes have acquired additional functions compared with the ancestral fabp1 gene, i.e., by neofunctionalization.
Title: Tandem duplication of the fabp1b gene and subsequent divergence of the tissue-specific distribution of fabp1b.1 and fabp1b.2 transcripts in zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to lipid	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: fatty acid binding protein 1-B.1

Names: zf-FABP1b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.