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plpp6 phospholipid phosphatase 6 [ Danio rerio (zebrafish) ]

Gene ID: 553687, updated on 18-Sep-2024

Summary

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Official Symbol
plpp6provided by ZNC
Official Full Name
phospholipid phosphatase 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-247
See related
Ensembl:ENSDARG00000043527 AllianceGenome:ZFIN:ZDB-GENE-040724-247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ppapdc2; zgc:112181; si:ch211-191d7.4; si:ch211-246k22.2
Summary
Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human PLPP6 (phospholipid phosphatase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See plpp6 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (15149421..15161669, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (15252219..15262166, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:dkey-239i20.4 Neighboring gene flavin containing dimethylaniline monoxygenase 5 Neighboring gene peroxiredoxin 6 Neighboring gene uncharacterized LOC137488626

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish. Chatzopoulou A, et al. Endocrinology, 2015 May. PMID 25756310
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC112181

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingosine-1-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in farnesyl diphosphate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in geranyl diphosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in geranylgeranyl diphosphate catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein prenylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6
Names
phosphatidic acid phosphatase type 2 domain-containing protein 2
presqualene diphosphate phosphatase
NP_001315267.1
NP_001315268.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328338.1 → NP_001315267.1  polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX255937, EH434738
    UniProtKB/Swiss-Prot
    Q502I4, Q5TZ07, Q5TZD1
    UniProtKB/TrEMBL
    A0A8M1P4M7, T1ECT0
    Related
    ENSDARP00000074783.4, ENSDART00000080333.5
    Conserved Domains (2) summary
    COG0671
    Location:202 → 265
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03391
    Location:113 → 271
    PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...

  2. NM_001328339.1 → NP_001315268.1  polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX255937, EH434738
    UniProtKB/TrEMBL
    A0A2U3TVI8, A0A8M1P9S7
    Related
    ENSDARP00000063881.4, ENSDART00000063882.4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    15149421..15161669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_011007678.1 RNA Sequence

  2. XR_011007679.1 RNA Sequence

  3. XR_011007675.1 RNA Sequence

  4. XR_011007680.1 RNA Sequence

  5. XR_011007681.1 RNA Sequence

  6. XR_011007676.1 RNA Sequence

  7. XR_011007677.1 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395065.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    106231..116076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001020662.1: Suppressed sequence

    Description
    NM_001020662.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TZ07.1 GenPept UniProtKB/Swiss-Prot:Q5TZ07

Gene LinkOut

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