gmpr guanosine monophosphate reductase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gmprprovided by ZNC
Official Full Name: guanosine monophosphate reductaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-48
See related: Ensembl:ENSDARG00000016160 AllianceGenome:ZFIN:ZDB-GENE-050522-48
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:110617
Summary: Predicted to enable GMP reductase activity and metal ion binding activity. Predicted to be involved in purine nucleotide metabolic process. Predicted to act upstream of or within nucleotide metabolic process and purine nucleobase metabolic process. Predicted to be part of GMP reductase complex. Orthologous to human GMPR (guanosine monophosphate reductase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (32472996..32487275, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (32885876..32900155, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb02a09.x1 (e-PCR)
- UniSTS:189804

fc23d08.x1 (e-PCR)
- UniSTS:193148

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GMP reductase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GMP reductase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GMP reductase 1

NP_001018448.1

EC 1.7.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020612.1 → NP_001018448.1 GMP reductase 1

See identical proteins and their annotated locations for NP_001018448.1

Status: PROVISIONAL

Source sequence(s)

BC095337

UniProtKB/TrEMBL

B2GNZ5, F6NHF5, Q503G5

Related

ENSDARP00000050129.4, ENSDART00000050130.6

Conserved Domains (2) summary

PRK05096
Location:3 → 345

PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

cd00381
Location:10 → 336

IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...