ngly1 N-glycanase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ngly1provided by ZNC
Official Full Name: N-glycanase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-535
See related: Ensembl:ENSDARG00000003205 AllianceGenome:ZFIN:ZDB-GENE-050522-535
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:6895151; zgc:110561
Summary: Predicted to enable peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Acts upstream of or within peripheral nervous system neuron axonogenesis; skeletal muscle tissue development; and swimming behavior. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in brain; caudal fin; peripheral nervous system; and spinal cord. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 1. Orthologous to human NGLY1 (N-glycanase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (20761670..20777190, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (21177347..21192867, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycoprotein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoprotein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peripheral nervous system neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Names: PNGase; peptide:N-glycanase

NP_001018437.1

EC 3.5.1.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020601.1 → NP_001018437.1 peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

See identical proteins and their annotated locations for NP_001018437.1

Status: PROVISIONAL

Source sequence(s)

BC095313

UniProtKB/Swiss-Prot

Q503I8

UniProtKB/TrEMBL

B2GSS9

Related

ENSDARP00000008500.5, ENSDART00000019206.6

Conserved Domains (5) summary

cd10459
Location:7 → 99

PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)

COG1305
Location:278 → 355

YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]

pfam01841
Location:262 → 339

Transglut_core; Transglutaminase-like superfamily

pfam03835
Location:323 → 419

Rad4; Rad4 transglutaminase-like domain

pfam04721
Location:442 → 641

PAW; PNGase C-terminal domain, mannose-binding module PAW