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SLC22A15 solute carrier family 22 member 15 [ Homo sapiens (human) ]

Gene ID: 55356, updated on 3-Apr-2024

Summary

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Official Symbol
SLC22A15provided by HGNC
Official Full Name
solute carrier family 22 member 15provided by HGNC
Primary source
HGNC:HGNC:20301
See related
Ensembl:ENSG00000163393 MIM:608275; AllianceGenome:HGNC:20301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLIPT1; PRO34686
Summary
Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Expression
Broad expression in bone marrow (RPKM 6.8), skin (RPKM 3.1) and 19 other tissues See more
Orthologs
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Genomic context

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See SLC22A15 in Genome Data Viewer
Location:
1p13.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (115976513..116070054)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (115984504..116078027)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (116519134..116612675)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A-like Neighboring gene uncharacterized LOC101928977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:116470749-116471250 Neighboring gene long intergenic non-protein coding RNA 1649 Neighboring gene NANOG hESC enhancer GRCh37_chr1:116483799-116484300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1225 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:116531140-116531301 Neighboring gene NANOG hESC enhancer GRCh37_chr1:116590670-116591171 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:116609321-116610520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1556 Neighboring gene uncharacterized LOC105378918 Neighboring gene mab-21 like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1557 Neighboring gene Sharpr-MPRA regulatory region 11424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1227 Neighboring gene uncharacterized LOC124904384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1558

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. Yee SW, et al. FASEB J, 2020 Dec. PMID 33124720, Free PMC Article
  2. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. Eraly SA, et al. Biochem Biophys Res Commun, 2002 Oct 11. PMID 12372408
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Yang X, et al. Cell, 2016 Feb 11. PMID 26871637, Free PMC Article
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
    Title: Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. Flipts might have a role in carnitine transport, particularly in brain
    Title: Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761G0313

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amino-acid betaine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino-acid betaine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 22 member 15
Names
flipt 1
fly-like putative organic ion transporter 1
fly-like putative transporter 1
solute carrier family 22 (organic cation transporter), member 15
trans-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018420.3 → NP_060890.2  solute carrier family 22 member 15

    See identical proteins and their annotated locations for NP_060890.2

    Status: VALIDATED

    Source sequence(s)
    AL353933, AL357137, AL365318, BC026358, BC070033
    Consensus CDS
    CCDS44198.1
    UniProtKB/Swiss-Prot
    A8MUR3, Q6UXP5, Q8IZD6, Q8TAL9, Q9NSH5
    UniProtKB/TrEMBL
    A0A0S2Z6C8
    Related
    ENSP00000358515.4, ENST00000369503.9
    Conserved Domains (1) summary
    cd17377
    Location:71 → 469
    MFS_SLC22A15; Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    115976513..116070054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424416.1 → XP_047280372.1  solute carrier family 22 member 15 isoform X9

    UniProtKB/TrEMBL
    B3KWH0

  2. XM_047424412.1 → XP_047280368.1  solute carrier family 22 member 15 isoform X3

  3. XM_047424411.1 → XP_047280367.1  solute carrier family 22 member 15 isoform X2

  4. XM_047424415.1 → XP_047280371.1  solute carrier family 22 member 15 isoform X7

  5. XM_047424414.1 → XP_047280370.1  solute carrier family 22 member 15 isoform X5

  6. XM_024448239.2 → XP_024304007.1  solute carrier family 22 member 15 isoform X8

    UniProtKB/TrEMBL
    A0A0S2Z5P9
    Conserved Domains (1) summary
    cl26863
    Location:94 → 394
    Sugar_tr; Sugar (and other) transporter

  7. XM_024448238.2 → XP_024304006.1  solute carrier family 22 member 15 isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z5P9
    Conserved Domains (1) summary
    cl26863
    Location:94 → 394
    Sugar_tr; Sugar (and other) transporter

  8. XM_005271004.4 → XP_005271061.1  solute carrier family 22 member 15 isoform X10

    Conserved Domains (1) summary
    cd06174
    Location:111 → 246
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  9. XM_047424419.1 → XP_047280375.1  solute carrier family 22 member 15 isoform X12

  10. XM_047424420.1 → XP_047280376.1  solute carrier family 22 member 15 isoform X13

  11. XM_047424422.1 → XP_047280378.1  solute carrier family 22 member 15 isoform X15

    Related
    ENSP00000358514.1, ENST00000369502.1

  12. XM_047424417.1 → XP_047280373.1  solute carrier family 22 member 15 isoform X9

    UniProtKB/TrEMBL
    B3KWH0

  13. XM_047424413.1 → XP_047280369.1  solute carrier family 22 member 15 isoform X4

  14. XM_047424410.1 → XP_047280366.1  solute carrier family 22 member 15 isoform X1

  15. XM_047424418.1 → XP_047280374.1  solute carrier family 22 member 15 isoform X11

  16. XM_047424421.1 → XP_047280377.1  solute carrier family 22 member 15 isoform X14

RNA

  1. XR_002957027.2 RNA Sequence

  2. XR_002957032.2 RNA Sequence

  3. XR_007061934.1 RNA Sequence

  4. XR_007061933.1 RNA Sequence

  5. XR_007061932.1 RNA Sequence

  6. XR_007061935.1 RNA Sequence

  7. XR_007061937.1 RNA Sequence

  8. XR_007061936.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    115984504..116078027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337513.1 → XP_054193488.1  solute carrier family 22 member 15 isoform X9

    UniProtKB/TrEMBL
    B3KWH0

  2. XM_054337507.1 → XP_054193482.1  solute carrier family 22 member 15 isoform X3

  3. XM_054337506.1 → XP_054193481.1  solute carrier family 22 member 15 isoform X2

  4. XM_054337511.1 → XP_054193486.1  solute carrier family 22 member 15 isoform X7

  5. XM_054337509.1 → XP_054193484.1  solute carrier family 22 member 15 isoform X5

  6. XM_054337512.1 → XP_054193487.1  solute carrier family 22 member 15 isoform X8

  7. XM_054337510.1 → XP_054193485.1  solute carrier family 22 member 15 isoform X6

  8. XM_054337515.1 → XP_054193490.1  solute carrier family 22 member 15 isoform X10

  9. XM_054337517.1 → XP_054193492.1  solute carrier family 22 member 15 isoform X12

  10. XM_054337518.1 → XP_054193493.1  solute carrier family 22 member 15 isoform X13

  11. XM_054337520.1 → XP_054193495.1  solute carrier family 22 member 15 isoform X15

  12. XM_054337514.1 → XP_054193489.1  solute carrier family 22 member 15 isoform X9

    UniProtKB/TrEMBL
    B3KWH0

  13. XM_054337508.1 → XP_054193483.1  solute carrier family 22 member 15 isoform X4

  14. XM_054337505.1 → XP_054193480.1  solute carrier family 22 member 15 isoform X1

  15. XM_054337516.1 → XP_054193491.1  solute carrier family 22 member 15 isoform X11

  16. XM_054337519.1 → XP_054193494.1  solute carrier family 22 member 15 isoform X14

RNA

  1. XR_008486095.1 RNA Sequence

  2. XR_008486098.1 RNA Sequence

  3. XR_008486097.1 RNA Sequence

  4. XR_008486096.1 RNA Sequence

  5. XR_008486094.1 RNA Sequence

  6. XR_008486099.1 RNA Sequence

  7. XR_008486101.1 RNA Sequence

  8. XR_008486100.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZD6.1 GenPept UniProtKB/Swiss-Prot:Q8IZD6

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