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ABHD10 abhydrolase domain containing 10, depalmitoylase [ Homo sapiens (human) ]

Gene ID: 55347, updated on 7-Apr-2024

Summary

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Official Symbol
ABHD10provided by HGNC
Official Full Name
abhydrolase domain containing 10, depalmitoylaseprovided by HGNC
Primary source
HGNC:HGNC:25656
See related
Ensembl:ENSG00000144827 MIM:618756; AllianceGenome:HGNC:25656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in kidney (RPKM 20.6), thyroid (RPKM 19.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ABHD10 in Genome Data Viewer
Location:
3q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (111979026..111993368)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (114700126..114714476)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111697873..111712215)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain family B member 2 Neighboring gene uncharacterized LOC105374040 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:111577934-111578520 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:111578521-111579105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20226 Neighboring gene uncharacterized LOC124906336 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:111637713-111638912 Neighboring gene Sharpr-MPRA regulatory region 1117 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:111697515-111698074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:111704853-111705354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:111705355-111705854 Neighboring gene NANOG hESC enhancer GRCh37_chr3:111719684-111720311 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:111720792-111721991 Neighboring gene transgelin 3 Neighboring gene riboflavin kinase pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver. Ito Y, et al. Drug Metab Dispos, 2014 Dec. PMID 25217485
  2. The emerging role of human esterases. Fukami T, et al. Drug Metab Pharmacokinet, 2012. PMID 22813719
  3. Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition. Zuhl AM, et al. J Am Chem Soc, 2012 Mar 21. PMID 22400490, Free PMC Article
  4. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Li Q, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21078990, Free PMC Article
  5. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Cao Y, et al. Nat Chem Biol, 2019 Dec. PMID 31740833, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Which potently inhibited ABHD10 activity.
    Title: An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver.
  2. mitochondrial localization of rat Abhd10
    Title: ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.
  3. ABHD10 is responsible for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
    Title: Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11342, FLJ36272

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds TAS
Traceable Author Statement
more info
  
enables mycophenolic acid acyl-glucuronide esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular glucuronidation TAS
Traceable Author Statement
more info
  
involved_in glucuronoside catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
palmitoyl-protein thioesterase ABHD10, mitochondrial
Names
abhydrolase domain-containing protein 10, mitochondrial
acyl-protein thioesterase ABHD10
alpha/beta hydrolase domain-containing protein 10, mitochondrial
mycophenolic acid acyl-glucuronide esterase, mitochondrial
NP_001258998.1
NP_060864.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272069.2 → NP_001258998.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001258998.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL713726, CA427297, DB453330, DR760607
    Consensus CDS
    CCDS63718.1
    UniProtKB/Swiss-Prot
    Q9NUJ1
    Related
    ENSP00000418973.1, ENST00000494817.1
    Conserved Domains (1) summary
    COG0596
    Location:65 → 180
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. NM_018394.4 → NP_060864.1  palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_060864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL713726, BC014516, CA427297, DB453330
    Consensus CDS
    CCDS2963.1
    UniProtKB/Swiss-Prot
    B7Z6A8, C9IZX5, D3DN63, Q8TCF9, Q9NUJ1
    Related
    ENSP00000273359.3, ENST00000273359.8
    Conserved Domains (1) summary
    COG0596
    Location:65 → 291
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RNA

  1. NR_073570.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300018, AL713726, CA427297

  2. NR_073571.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK300018, AL713726, CA427297, DB453330, DB494690

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    111979026..111993368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    114700126..114714476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUJ1.1 GenPept UniProtKB/Swiss-Prot:Q9NUJ1

Gene LinkOut

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