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gabrg2 gamma-aminobutyric acid type A receptor subunit gamma2 [ Danio rerio (zebrafish) ]

Gene ID: 553402, updated on 2-Nov-2024

Summary

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Official Symbol
gabrg2provided by ZNC
Official Full Name
gamma-aminobutyric acid type A receptor subunit gamma2provided by ZNC
Primary source
ZFIN:ZDB-GENE-091118-65
See related
Ensembl:ENSDARG00000053665 AllianceGenome:ZFIN:ZDB-GENE-091118-65
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-145n14.1
Summary
Contributes to GABA-gated chloride ion channel activity. Acts upstream of or within protein heterotrimerization. Predicted to be located in membrane. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in dendrite membrane and postsynapse. Is expressed in brain; brainstem; and eye. Used to study epilepsy. Human ortholog(s) of this gene implicated in alcohol dependence; alcoholic liver cirrhosis; amphetamine abuse; brain disease (multiple); and heroin dependence. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gabrg2 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (41903462..42007482, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (41890251..41994375, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 14 Neighboring gene endonuclease, polyU-specific 2 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha1 Neighboring gene uncharacterized LOC137488845

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models. Choo BKM, et al. Biomed Pharmacother, 2021 Oct. PMID 34411917
  2. Interactions of Fipronil within Fish and Insects: Experimental and Molecular Modeling Studies. Zhang B, et al. J Agric Food Chem, 2018 Jun 13. PMID 29627978
  3. Interaction of insecticides with heteromeric GABA-gated chloride channels from zebrafish Danio rerio (Hamilton). Huang QT, et al. J Hazard Mater, 2019 Mar 15. PMID 30580138
  4. Targeted knockout of GABA-A receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae. Liao M, et al. Dis Model Mech, 2019 Nov 11. PMID 31582559, Free PMC Article
  5. The GABRG2 F343L allele causes spontaneous seizures in a novel transgenic zebrafish model that can be treated with suberanilohydroxamic acid (SAHA). Shen D, et al. Ann Transl Med, 2020 Dec. PMID 33437759, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to GABA-gated chloride ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to benzodiazepine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein heterotrimerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit gamma-2
Names
gamma-aminobutyric acid (GABA) A receptor, gamma 2
gamma-aminobutyric acid A receptor, gamma 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256250.1 → NP_001243179.1  gamma-aminobutyric acid receptor subunit gamma-2 precursor

    Status: VALIDATED

    Source sequence(s)
    CABZ01068454, CABZ01068455, CR847531
    UniProtKB/TrEMBL
    A0A8M1P4D6
    Related
    ENSDARP00000134746.2, ENSDART00000165743.2
    Conserved Domains (3) summary
    TIGR00860
    Location:69 → 473
    LIC; Cation transporter family protein
    pfam02931
    Location:67 → 272
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:279 → 470
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    41903462..42007482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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