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fto FTO alpha-ketoglutarate dependent dioxygenase [ Danio rerio (zebrafish) ]

Gene ID: 553363, updated on 17-Sep-2024

Summary

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Official Symbol
ftoprovided by ZNC
Official Full Name
FTO alpha-ketoglutarate dependent dioxygenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061108-1
See related
Ensembl:ENSDARG00000044216 AllianceGenome:ZFIN:ZDB-GENE-061108-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Acts upstream of or within several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See fto in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (36111331..36358340, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (35839993..36086821, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496182 Neighboring gene iroquois homeobox 3a Neighboring gene uncharacterized LOC137496183 Neighboring gene nucleolar protein 58-like Neighboring gene akt interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular characterization and expression analysis of fat mass and obesity-associated gene in rabbit. Xing J, et al. J Genet, 2013 Dec. PMID 24371169
  2. Obesity-associated variants within FTO form long-range functional connections with IRX3. Smemo S, et al. Nature, 2014 Mar 20. PMID 24646999, Free PMC Article
  3. Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. Osborn DP, et al. PLoS One, 2014. PMID 24503721, Free PMC Article
  4. Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. Sun Q, et al. Int J Biol Sci, 2017. PMID 28924386, Free PMC Article
  5. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Ragvin A, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080751, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.
    Title: Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables broad specificity oxidative DNA demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables broad specificity oxidative DNA demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA N6-methyladenosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA N6-methyladenosine dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidative RNA demethylase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA alkylation repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein fto; alpha-ketoglutarate-dependent dioxygenase FTO
Names
fat mass and obesity associated
XP_001345910.5
XP_009301626.1
XP_021327673.1
XP_021327674.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    36111331..36358340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303351.4 → XP_009301626.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

    UniProtKB/TrEMBL
    A0A2R8PY24, A0A8M9PKY4
    Related
    ENSDARP00000145984.1, ENSDART00000188392.1
    Conserved Domains (2) summary
    pfam12933
    Location:47 → 401
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:405 → 574
    FTO_CTD; FTO C-terminal domain

  2. XM_001345874.8 → XP_001345910.5  alpha-ketoglutarate-dependent dioxygenase FTO isoform X2

    Related
    ENSDARP00000107656.2, ENSDART00000130028.4

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394700.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    37818..269274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471999.2 → XP_021327674.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

    UniProtKB/TrEMBL
    A0A8M1PZX3
    Conserved Domains (2) summary
    pfam12933
    Location:47 → 401
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:405 → 574
    FTO_CTD; FTO C-terminal domain

  2. XM_021471998.2 → XP_021327673.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

    UniProtKB/TrEMBL
    A0A2R8PY24, A0A8M9PKY4
    Conserved Domains (2) summary
    pfam12933
    Location:47 → 401
    FTO_NTD; FTO catalytic domain
    pfam12934
    Location:405 → 574
    FTO_CTD; FTO C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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