U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC39A9 solute carrier family 39 member 9 [ Homo sapiens (human) ]

Gene ID: 55334, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SLC39A9provided by HGNC
Official Full Name
solute carrier family 39 member 9provided by HGNC
Primary source
HGNC:HGNC:20182
See related
Ensembl:ENSG00000029364 MIM:619116; AllianceGenome:HGNC:20182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP9; ZIP-9
Summary
Predicted to enable metal ion transmembrane transporter activity. Predicted to be involved in transmembrane transport and zinc ion transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 15.0), kidney (RPKM 14.8) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLC39A9 in Genome Data Viewer
Location:
14q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (69398384..69462390)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (63611539..63675542)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (69865101..69929107)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 16 Neighboring gene uncharacterized LOC105370549 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69800956-69801456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69801457-69801957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:69815418-69815918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8636 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69864016-69864524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:69864525-69865032 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:69865025-69865265 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:69865234-69866433 Neighboring gene ERH mRNA splicing and mitosis factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5881 Neighboring gene pleckstrin homology and coiled-coil domain containing D1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36437 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70014029-70014585 Neighboring gene RPL24 pseudogene 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma. Aguirre-Portolés C, et al. Cancer Res, 2021 Dec 1. PMID 34706862, Free PMC Article
  2. Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling. Chen J, et al. Oncogene, 2020 Jan. PMID 31506605
  3. Genome-Wide Analysis Reveals Zinc Transporter ZIP9 Regulated by DNA Methylation Promotes Radiation-Induced Skin Fibrosis via the TGF-β Signaling Pathway. Qiu Y, et al. J Invest Dermatol, 2020 Jan. PMID 31254515
  4. ZIP9 but not the androgen receptor mediates testosterone-induced migratory activity of metastatic prostate cancer cells. Bulldan A, et al. Biochim Biophys Acta Mol Cell Res, 2018 Dec. PMID 30262433
  5. Testosterone/bicalutamide antagonism at the predicted extracellular androgen binding site of ZIP9. Bulldan A, et al. Biochim Biophys Acta Mol Cell Res, 2017 Dec. PMID 28943399

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Androgens promote vascular endothelial cell proliferation through activation of a ZIP9-dependent inhibitory G protein/PI3K-Akt/Erk/cyclin D1 pathway.
    Title: Androgens promote vascular endothelial cell proliferation through activation of a ZIP9-dependent inhibitory G protein/PI3K-Akt/Erk/cyclin D1 pathway.
  2. ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma.
    Title: ZIP9 Is a Druggable Determinant of Sex Differences in Melanoma.
  3. these data illustrate epigenetic regulation of ZIP9 and its critical role in promoting radiation-induced skin fibrosis
    Title: Genome-Wide Analysis Reveals Zinc Transporter ZIP9 Regulated by DNA Methylation Promotes Radiation-Induced Skin Fibrosis via the TGF-β Signaling Pathway.
  4. Study found that the androgen dihydrotestosterone (DHT) might function via a novel membrane androgen receptor (mAR-SLC39A9) to increase nuclear androgen receptor (nAR)-negative bladder cancer (BCa) cell migration and invasion. DHT/mAR-SLC39A9 might function by altering Galphai protein-mediated MAPK/MMP9 intracellular signaling to increase nAR-negative BCa cell migration and invasion.
    Title: Androgen dihydrotestosterone (DHT) promotes the bladder cancer nuclear AR-negative cell invasion via a newly identified membrane androgen receptor (mAR-SLC39A9)-mediated Gαi protein/MAPK/MMP9 intracellular signaling.
  5. The G protein-coupled receptor family C group 6 member A (GPRC6A) and zinc transporter member 9 (ZIP9) have also been portrayed as mARs, related to the extranuclear action of androgens.
    Title: Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression.
  6. Study provides evidence that mediates testosterone-induced migratory activity of metastatic prostate cancer cells.
    Title: ZIP9 but not the androgen receptor mediates testosterone-induced migratory activity of metastatic prostate cancer cells.
  7. The study connects structural features of ZIP9 to its functions and indicates a possible relevance of ZIP9 as a pharmacological target
    Title: Testosterone/bicalutamide antagonism at the predicted extracellular androgen binding site of ZIP9.
  8. ZIP9 role glioblastoma cells migration.ZIP9 expression affects phosphorylation states of p53 and GSK-3beta.
    Title: Expression of the zinc importer protein ZIP9/SLC39A9 in glioblastoma cells affects phosphorylation states of p53 and GSK-3β and causes increased cell migration.
  9. The results show ZIP9 is a specific Gi coupled-mAR mediating testosterone-induced MAP kinase and zinc signaling in PC3-ZIP9 cells.
    Title: Membrane androgen receptor characteristics of human ZIP9 (SLC39A) zinc transporter in prostate cancer cells: Androgen-specific activation and involvement of an inhibitory G protein in zinc and MAP kinase signaling.
  10. ZIP9 expression in glioma tumors was not associated with tumor grade or IDH1 mutation status.
    Title: Expression Profile Analysis of Zinc Transporters (ZIP4, ZIP9, ZIP11, ZnT9) in Gliomas and their Correlation with IDH1 Mutation Status.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ11274, MGC74989

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables androgen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in bicellular tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular zinc ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular response to testosterone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zinc transporter ZIP9
Names
ZRT/IRT-like protein 9
solute carrier family 39 (zinc transporter), member 9
zinc transporter 9
zinc transporter SLC39A9
zrt- and Irt-like protein 9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252148.2 → NP_001239077.1  zinc transporter ZIP9 isoform 2

    See identical proteins and their annotated locations for NP_001239077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL137760, AY358687, AY780789, BX643103, DA112731
    Consensus CDS
    CCDS58328.1
    UniProtKB/Swiss-Prot
    Q9NUM3
    Related
    ENSP00000451833.1, ENST00000557046.1
    Conserved Domains (1) summary
    cl00437
    Location:9 → 278
    Zip; ZIP Zinc transporter

  2. NM_001252150.2 → NP_001239079.1  zinc transporter ZIP9 isoform 3

    See identical proteins and their annotated locations for NP_001239079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA884056, AK222547, BC047682, BP269907
    Consensus CDS
    CCDS58327.1
    UniProtKB/Swiss-Prot
    Q9NUM3
    Related
    ENSP00000452385.1, ENST00000556605.5
    Conserved Domains (1) summary
    cl00437
    Location:9 → 220
    Zip; ZIP Zinc transporter

  3. NM_001252151.2 → NP_001239080.1  zinc transporter ZIP9 isoform 4

    See identical proteins and their annotated locations for NP_001239080.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream, in-frame start codon, compared to variant 1. Variants 4 and 5 both encode isoform (4), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK293222, AL137760, AY358687, BP299863
    UniProtKB/TrEMBL
    B4DDK0
    Conserved Domains (1) summary
    cl00437
    Location:13 → 183
    Zip; ZIP Zinc transporter

  4. NM_001252152.2 → NP_001239081.1  zinc transporter ZIP9 isoform 4

    See identical proteins and their annotated locations for NP_001239081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, includes an alternate internal exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4 and 5 both encode isoform (4), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK316381, AL137760, AY358687, BP299863
    UniProtKB/TrEMBL
    B4DDK0
    Conserved Domains (1) summary
    cl00437
    Location:13 → 183
    Zip; ZIP Zinc transporter

  5. NM_001330185.2 → NP_001317114.1  zinc transporter ZIP9 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AL137760, AL157996
    Consensus CDS
    CCDS81816.1
    UniProtKB/TrEMBL
    M0QX28
    Related
    ENSP00000468864.1, ENST00000031146.8
    Conserved Domains (1) summary
    cl00437
    Location:68 → 235
    Zip; ZIP Zinc transporter

  6. NM_018375.5 → NP_060845.2  zinc transporter ZIP9 isoform 1

    See identical proteins and their annotated locations for NP_060845.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL137760, AY358687, DA112731
    Consensus CDS
    CCDS9795.1
    UniProtKB/Swiss-Prot
    G3V5J8, Q53HN3, Q5MJQ0, Q6P2Q1, Q86WY2, Q9NUM3
    UniProtKB/TrEMBL
    C4N9M8
    Related
    ENSP00000336887.5, ENST00000336643.10
    Conserved Domains (1) summary
    pfam02535
    Location:9 → 301
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    69398384..69462390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449648.2 → XP_024305416.1  zinc transporter ZIP9 isoform X1

    UniProtKB/TrEMBL
    B4DDK0
    Conserved Domains (1) summary
    cl00437
    Location:13 → 183
    Zip; ZIP Zinc transporter

  2. XM_047431550.1 → XP_047287506.1  zinc transporter ZIP9 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    63611539..63675542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376327.1 → XP_054232302.1  zinc transporter ZIP9 isoform X1

    UniProtKB/TrEMBL
    B4DDK0

  2. XM_054376328.1 → XP_054232303.1  zinc transporter ZIP9 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUM3.2 GenPept UniProtKB/Swiss-Prot:Q9NUM3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous