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lamb2l laminin, beta 2-like [ Danio rerio (zebrafish) ]

Gene ID: 553337, updated on 12-Sep-2024

Summary

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Official Symbol
lamb2lprovided by ZNC
Official Full Name
laminin, beta 2-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4205
See related
Ensembl:ENSDARG00000033950 AllianceGenome:ZFIN:ZDB-GENE-030131-4205
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc83a09; wu:fc83a09; si:dkey-32e6.1
Summary
Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including basement membrane assembly; cell migration; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be part of laminin complex. Is expressed in several structures, including head; nervous system; neural tube; otic vesicle; and pronephric duct. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See lamb2l in Genome Data Viewer
Location:
chromosome: 23
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20262929..20338584, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20336586..20412428, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 19 Neighboring gene laminin, beta 2 (laminin S) Neighboring gene si:rp71-17i16.6 Neighboring gene si:rp71-17i16.5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment. Jacoby AS, et al. Development, 2009 Oct. PMID 19736328, Free PMC Article
  2. Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages. Nagendran M, et al. Development, 2015 Jan 15. PMID 25519245, Free PMC Article
  3. Characterization of the laminin gene family and evolution in zebrafish. Sztal T, et al. Dev Dyn, 2011 Feb. PMID 21246659
  4. Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). Zhao N, et al. Int J Mol Sci, 2022 Sep 10. PMID 36142434, Free PMC Article
  5. Proteomics analysis of the zebrafish skeletal extracellular matrix. Kessels MY, et al. PLoS One, 2014. PMID 24608635, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in basement membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of laminin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
laminin subunit beta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    20262929..20338584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_687746.10 → XP_692838.6  laminin subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_692838.6

    UniProtKB/TrEMBL
    A0A8M9PDX2, F1QD37
    Related
    ENSDARP00000048365.7, ENSDART00000048366.8
    Conserved Domains (5) summary
    smart00180
    Location:816 → 861
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:454 → 505
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:864 → 912
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:41 → 266
    Laminin_N; Laminin N-terminal (Domain VI)
    cl25732
    Location:1243 → 1826
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_005162121.5 → XP_005162178.1  laminin subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_005162178.1

    UniProtKB/TrEMBL
    A0A8M9PDX2, F1QD37
    Conserved Domains (5) summary
    smart00180
    Location:816 → 861
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:454 → 505
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:864 → 912
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:41 → 266
    Laminin_N; Laminin N-terminal (Domain VI)
    cl25732
    Location:1243 → 1826
    SMC_N; RecF/RecN/SMC N terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395143.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    92..61262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473632.2 → XP_021329307.1  laminin subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PDX2, F1QD37
    Conserved Domains (5) summary
    smart00180
    Location:816 → 861
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:454 → 505
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:864 → 912
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:41 → 266
    Laminin_N; Laminin N-terminal (Domain VI)
    cl25732
    Location:1243 → 1826
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021473631.2 → XP_021329306.1  laminin subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PDX2, F1QD37
    Conserved Domains (5) summary
    smart00180
    Location:816 → 861
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    cd00055
    Location:454 → 505
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:864 → 912
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:41 → 266
    Laminin_N; Laminin N-terminal (Domain VI)
    cl25732
    Location:1243 → 1826
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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