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DRAM1 DNA damage regulated autophagy modulator 1 [ Homo sapiens (human) ]

Gene ID: 55332, updated on 3-Apr-2024

Summary

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Official Symbol
DRAM1provided by HGNC
Official Full Name
DNA damage regulated autophagy modulator 1provided by HGNC
Primary source
HGNC:HGNC:25645
See related
Ensembl:ENSG00000136048 MIM:610776; AllianceGenome:HGNC:25645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAM
Summary
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 41.9), urinary bladder (RPKM 12.1) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
12q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (101877580..101923612)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (101838785..101884733)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (102271358..102317390)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1183, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:102270762-102271544 and GRCh37_chr12:102271545-102272326 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_22782 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:102317122-102318321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6874 Neighboring gene Sharpr-MPRA regulatory region 5561 Neighboring gene ribosomal protein L9 pseudogene 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6876 Neighboring gene uncharacterized LOC107984548 Neighboring gene neudesin neurotrophic factor pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling. Feng Q, et al. Acta Histochem, 2022 Apr. PMID 35299128
  2. DRAM1 deficiency affects the organization and function of the Golgi apparatus. Wei M, et al. Cell Signal, 2019 Nov. PMID 31356858
  3. DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway. Lu T, et al. Cell Commun Signal, 2019 Mar 22. PMID 30902093, Free PMC Article
  4. Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux. Wu X, et al. J Mol Cell Cardiol, 2018 Nov. PMID 30144448
  5. Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria. Liu K, et al. Cell Death Dis, 2014 Feb 20. PMID 24556693, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling.
    Title: ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling.
  2. DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling.
    Title: DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling.
  3. DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
    Title: DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
  4. DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR.
    Title: DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR.
  5. DRAM1 deficiency affects the organization and function of the Golgi apparatus.
    Title: DRAM1 deficiency affects the organization and function of the Golgi apparatus.
  6. The expression of serum DRAM1 messenger RNA (mRNA), ARSA mRNA, hsa-miR-2053 and lncRNA-RP1-86D1.3 were positive in 78.3%, 90%, 85%, and 83.3% of MPM patients, respectively.
    Title: Clinical significance of serum DRAM1 mRNA, ARSA mRNA, hsa-miR-2053 and lncRNA-RP1-86D1.3 axis expression in malignant pleural mesothelioma.
  7. DRAM-1 binds the membrane carrier protein SCAMP3 and the amino acid transporters SLC1A5 and LAT1, directing them to lysosomes and permitting efficient mTORC1 activation.
    Title: mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.
  8. Our results indicated that DRAM1 protected cardiomyocytes from ischemia stress-induced autophagy flux obstacle and uncovered a novel DRAM1-Atg7-Atg12/Atg5 autophagy flux regulation pathway under conditions of myocardial ischemic stress.
    Title: Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux.
  9. these results identify that the class I PI3K-Akt-rpS6 pathway is regulated by DRAM1 and may provide new insight into the potential role of DRAM1 in human cancers.
    Title: DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway.
  10. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53-dependent apoptosis (PUMA) and autophagy (DRAM) gene occurred, modifying the ADR-induced cancer cell death in HG both in vitro and in vivo.
    Title: p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11259

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA damage-regulated autophagy modulator protein 1
Names
damage-regulated autophagy modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018370.3 → NP_060840.2  DNA damage-regulated autophagy modulator protein 1

    See identical proteins and their annotated locations for NP_060840.2

    Status: REVIEWED

    Source sequence(s)
    AC084398, AI079438, BC018435
    Consensus CDS
    CCDS41823.1
    UniProtKB/Swiss-Prot
    B7Z4T0, Q7L3E3, Q8N682, Q9NUN1
    UniProtKB/TrEMBL
    B3KT44
    Related
    ENSP00000258534.8, ENST00000258534.13
    Conserved Domains (1) summary
    pfam10277
    Location:7 → 224
    Frag1; Frag1/DRAM/Sfk1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    101877580..101923612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269004.3 → XP_005269061.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

    UniProtKB/TrEMBL
    B3KT44
    Conserved Domains (1) summary
    pfam10277
    Location:7 → 188
    Frag1; Frag1/DRAM/Sfk1 family

  2. XM_005269005.3 → XP_005269062.1  DNA damage-regulated autophagy modulator protein 1 isoform X3

    Related
    ENSP00000445827.1, ENST00000544152.5
    Conserved Domains (1) summary
    pfam10277
    Location:7 → 146
    Frag1; Frag1/DRAM/Sfk1 family

  3. XM_047429098.1 → XP_047285054.1  DNA damage-regulated autophagy modulator protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    101838785..101884733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372449.1 → XP_054228424.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

  2. XM_054372451.1 → XP_054228426.1  DNA damage-regulated autophagy modulator protein 1 isoform X3

  3. XM_054372450.1 → XP_054228425.1  DNA damage-regulated autophagy modulator protein 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N682.1 GenPept UniProtKB/Swiss-Prot:Q8N682

Gene LinkOut

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