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pcxa pyruvate carboxylase a [ Danio rerio (zebrafish) ]

Gene ID: 553283, updated on 17-Aug-2024

Summary

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Official Symbol
pcxaprovided by ZNC
Official Full Name
pyruvate carboxylase aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090908-3
See related
Ensembl:ENSDARG00000098766 AllianceGenome:ZFIN:ZDB-GENE-090908-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pcl; PYCa; zgc:123047
Summary
Predicted to enable pyruvate carboxylase activity. Acts upstream of or within habituation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 21
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (26733345..26966059)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (26696650..26929364)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 3 member 2b Neighboring gene calmodulin 3b (phosphorylase kinase, delta) Neighboring gene uncharacterized LOC101883097 Neighboring gene uncharacterized LOC101883049 Neighboring gene leucine rich repeat and fibronectin type III domain containing 4a Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Ba Neighboring gene FKBP prolyl isomerase 2 Neighboring gene solute carrier family 8 member 4a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning. Wolman MA, et al. Neuron, 2015 Mar 18. PMID 25754827, Free PMC Article
  2. Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Liu Y, et al. Front Genet, 2020. PMID 32849832, Free PMC Article
  3. Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Nolte H, et al. J Proteome Res, 2014 Apr 4. PMID 24611545
  4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC123047

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within habituation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pyruvate carboxylase a
Names
pyruvate carboxylase, like
NP_001315285.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328356.1 → NP_001315285.1  pyruvate carboxylase a

    Status: VALIDATED

    Source sequence(s)
    BX324223, BX465183, BX465841, BX530073
    UniProtKB/TrEMBL
    A0A0R4IFJ4, A0A8M1P3R3
    Related
    ENSDARP00000132084.1, ENSDART00000168379.2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    26733345..26966059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037670.1: Suppressed sequence

    Description
    NM_001037670.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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