mtdhb metadherin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtdhbprovided by ZNC
Official Full Name: metadherin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090929-2
See related: Ensembl:ENSDARG00000004939 AllianceGenome:ZFIN:ZDB-GENE-090929-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of apoptotic process; positive regulation of angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. Predicted to be active in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (41717309..41732539)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (41767267..41782636)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain