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ptgr2 prostaglandin reductase 2 [ Danio rerio (zebrafish) ]

Gene ID: 553234, updated on 2-Nov-2024

Summary

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Official Symbol
ptgr2provided by ZNC
Official Full Name
prostaglandin reductase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050506-71
See related
Ensembl:ENSDARG00000070673 AllianceGenome:ZFIN:ZDB-GENE-050506-71
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:6903726; si:dkey-119a7.6
Summary
Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be located in cytoplasm. Is expressed in nervous system; optic vesicle; proneural cluster; and somite. Orthologous to human PTGR2 (prostaglandin reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ptgr2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (37287844..37299394, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (37340259..37351809, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b Neighboring gene transmembrane protein 62 Neighboring gene mitotic deacetylase associated SANT domain protein b Neighboring gene cysteine-rich protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prostaglandin reductase 2
NP_001243152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256223.1 → NP_001243152.1  prostaglandin reductase 2

    Status: PROVISIONAL

    Source sequence(s)
    BC077125
    UniProtKB/TrEMBL
    A0A8M1P4D1, Q6DEI9
    Related
    ENSDARP00000129023.1, ENSDART00000154414.2
    Conserved Domains (2) summary
    cd08293
    Location:2 → 346
    PTGR2; Prostaglandin reductase
    COG2130
    Location:6 → 348
    CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    37287844..37299394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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