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st8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Danio rerio (zebrafish) ]

Gene ID: 553210, updated on 2-Nov-2024

Summary

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Official Symbol
st8sia1provided by ZNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-051005-1
See related
Ensembl:ENSDARG00000098221 AllianceGenome:ZFIN:ZDB-GENE-051005-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
siat 8A; zgc:158304
Summary
Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to act upstream of or within protein glycosylation and sphingolipid metabolic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including corpuscles of Stannius; forebrain neural plate; kidney; nervous system; and unfertilized egg. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See st8sia1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (26303610..26322836, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (26314412..26333638, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491555 Neighboring gene uncharacterized LOC137491557 Neighboring gene troponin I, skeletal, slow d Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Developmental regulation of oligosialylation in zebrafish. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18704683
  2. Molecular evolution and expression of zebrafish St8SiaIII, an alpha-2,8-sialyltransferase involved in myotome development. Bentrop J, et al. Dev Dyn, 2008 Mar. PMID 18265011
  3. Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation. Chang LY, et al. Int J Mol Sci, 2019 Jan 31. PMID 30709055, Free PMC Article
  4. Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18642128
  5. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Names
alpha-2,8-sialyltransferase ST8Sia I
NP_001075101.1
NP_001314770.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081632.1 → NP_001075101.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001075101.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    BC128837
    UniProtKB/TrEMBL
    A0A8M1ND26, A1A5W4
    Related
    ENSDARP00000134208.1, ENSDART00000161687.2
    Conserved Domains (1) summary
    pfam00777
    Location:72 → 145
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001327841.1 → NP_001314770.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CT573128, CU137645
    UniProtKB/TrEMBL
    A3KQF4, Q6KC13
    Related
    ENSDARP00000136671.1, ENSDART00000170709.2
    Conserved Domains (1) summary
    pfam00777
    Location:72 → 323
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    26303610..26322836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394557.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    3538..5225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395233.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    3538..5225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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