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GIMAP4 GTPase, IMAP family member 4 [ Homo sapiens (human) ]

Gene ID: 55303, updated on 5-Mar-2024

Summary

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Official Symbol
GIMAP4provided by HGNC
Official Full Name
GTPase, IMAP family member 4provided by HGNC
Primary source
HGNC:HGNC:21872
See related
Ensembl:ENSG00000133574 MIM:608087; AllianceGenome:HGNC:21872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAN1; IAN-1; IMAP4; MSTP062
Summary
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 64.9), spleen (RPKM 59.9) and 22 other tissues See more
Orthologs
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Genomic context

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See GIMAP4 in Genome Data Viewer
Location:
7q36.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150567390..150573953)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151745701..151752264)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150264478..150271041)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 3 Neighboring gene endogenous retrovirus group K member 19 Env polyprotein-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26835 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 2 Neighboring gene TRPC6 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic Value of GIMAP4 and Its Role in Promoting Immune Cell Infiltration into Tumor Microenvironment of Lung Adenocarcinoma. Chen S, et al. Biomed Res Int, 2022. PMID 36246963, Free PMC Article
  2. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease. Lee YJ, et al. Ann Rheum Dis, 2013 Sep 1. PMID 23041938
  3. Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation. Heinonen MT, et al. Immunol Cell Biol, 2015 Feb. PMID 25287446, Free PMC Article
  4. Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation. Filén JJ, et al. Mol Cell Proteomics, 2009 Jan. PMID 18701445, Free PMC Article
  5. Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells. Cambot M, et al. Blood, 2002 May 1. PMID 11964296

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prognostic Value of GIMAP4 and Its Role in Promoting Immune Cell Infiltration into Tumor Microenvironment of Lung Adenocarcinoma.
    Title: Prognostic Value of GIMAP4 and Its Role in Promoting Immune Cell Infiltration into Tumor Microenvironment of Lung Adenocarcinoma.
  2. GIMAP4 regulates secretion of cytokines in early differentiating human CD4(+) T helper lymphocytes and in particular the secretion of interferon-gamma also affecting its downstream targets.
    Title: Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation.
  3. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease
    Title: Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  5. GIMAP1 and GIMAP4 genes are up-regulated by IL-12 and other Th1 differentiation-inducing cytokines in cells induced to differentiate toward Th1 lineage and down-regulated by IL-4 in cells induced to Th2.
    Title: Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation.
  6. molecular and genetic properties; expression in resting T- and B-cells and decreased expression during lymphocyte activation
    Title: Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11110

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
GTPase IMAP family member 4
Names
human immune associated nucleotide 1
immune-associated nucleotide-binding protein 1
immunity associated protein 4
immunity-associated nucleotide 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363532.2 → NP_001350461.1  GTPase IMAP family member 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AF117333, AK301441, DA161191
    Consensus CDS
    CCDS87564.1
    UniProtKB/TrEMBL
    B4DWA5, G5E9W9
    Related
    ENSP00000419545.1, ENST00000461940.5
    Conserved Domains (2) summary
    cd01852
    Location:45 → 245
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
    cl27055
    Location:217 → 316
    MutS_III; MutS domain III

  2. NM_018326.3 → NP_060796.1  GTPase IMAP family member 4 isoform 1

    See identical proteins and their annotated locations for NP_060796.1

    Status: REVIEWED

    Source sequence(s)
    AF117333, BX476689
    Consensus CDS
    CCDS5904.1
    UniProtKB/Swiss-Prot
    Q9NUV9
    UniProtKB/TrEMBL
    A0A090N7X0, B4DWA5
    Related
    ENSP00000255945.2, ENST00000255945.4
    Conserved Domains (2) summary
    cd01852
    Location:31 → 231
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)
    cl27055
    Location:203 → 302
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150567390..150573953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151745701..151752264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUV9.1 GenPept UniProtKB/Swiss-Prot:Q9NUV9

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