paf1 PAF1 homolog, Paf1/RNA polymerase II complex component [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: paf1provided by ZNC
Official Full Name: PAF1 homolog, Paf1/RNA polymerase II complex componentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050506-101
See related: AllianceGenome:ZFIN:ZDB-GENE-050506-101
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: aln; paf1l; im:6906070; wu:fb80a09
Summary: Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Involved in heart development and neural crest cell development. Located in nucleus. Part of Cdc73/Paf1 complex. Orthologous to human PAF1 (PAF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (47616810..47625134)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (46784546..46792870, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PAF1 complex differentially regulates cardiomyocyte specification.
Title: The PAF1 complex differentially regulates cardiomyocyte specification.

Submit: New GeneRIF Correction

General gene information

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Markers

fb80a09.x1 (e-PCR)
- UniSTS:191523

fb80a09.x1 (e-PCR)
- UniSTS:191524

fc84h06.y1 (e-PCR)
- UniSTS:194635

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cdc73/Paf1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cdc73/Paf1 complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RNA polymerase II-associated factor 1 homolog

Names: PD2-like protein; paf1, RNA polymerase II associated factor, homolog, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.