BRF2 BRF2 RNA polymerase III transcription initiation factor subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: BRF2provided by HGNC
Official Full Name: BRF2 RNA polymerase III transcription initiation factor subunitprovided by HGNC
Primary source: HGNC:HGNC:17298
See related: Ensembl:ENSG00000104221 MIM:607013; AllianceGenome:HGNC:17298
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BRFU; TFIIIB50
Summary: This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 46.9), prostate (RPKM 42.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p11.23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (37843268..37849861, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (38119669..38126265, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (37700786..37707379, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma.
Title: A meta-analysis of BRF2 as a prognostic biomarker in invasive breast carcinoma.
TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma.
Title: TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma.
Silencing of BRF2 inhibits the growth and metastasis of lung cancer cells.
Title: Silencing of BRF2 inhibits the growth and metastasis of lung cancer cells.
MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2.
Title: MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2.
This study found a novel signaling pathway, namely MNX1-AS1/miR-527/BRF2 axis, involved in lung cancer progression.
Title: Long noncoding RNA MNX1-AS1 contributes to lung cancer progression through the miR-527/BRF2 pathway.
Results show that the mRNA and protein expression levels of BRF2 were markedly higher in non-small cell lung cancer (NSCLC) cells and highly related to differentiation degree, lymph node metastasis, clinical stage, and vascular invasion. miR-373 was identified to directly target BRF2, resulting in the enhanced migration and invasion of NSCLC A549 cells and indicating that BRF2 affects the metastasis of NSCLC.
Title: MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line.
REVIEW: highlights the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations
Title: New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.
Data indicate the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter.
Title: Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.
Study solved crystal structures of a human Brf2-TATA-binding complex bound to natural promoters, obtaining a detailed view of the molecular interactions occurring at Brf2-dependent Pol III promoters and highlighting the general structural and functional conservation of human Pol II and Pol III pre-initiation complexes.
Title: Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.
hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay.
Title: hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC33756 (e-PCR)
- UniSTS:32009

SHGC-57648 (e-PCR)
- UniSTS:78494

BRF2_3601 (e-PCR)
- UniSTS:462064

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription preinitiation complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIB complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor IIIB 50 kDa subunit

Names: B-related factor 2; BRF-2; BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like; RNA polymerase III transcription initiation factor BRFU; hBRFU; hTFIIIB50; transcription factor IIB- related factor, TFIIIB50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.