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PPP2R2B protein phosphatase 2 regulatory subunit Bbeta [ Homo sapiens (human) ]

Gene ID: 5521, updated on 3-Apr-2024

Summary

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Official Symbol
PPP2R2Bprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit Bbetaprovided by HGNC
Primary source
HGNC:HGNC:9305
See related
Ensembl:ENSG00000156475 MIM:604325; AllianceGenome:HGNC:9305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR52B; SCA12; B55BETA; PR55BETA; PP2ABBETA; PP2APR55B; PR2ABBETA; PR55-BETA; PP2AB55BETA; PR2AB55BETA; PP2APR55BETA; PR2APR55BETA
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. [provided by RefSeq, Jul 2016]
Expression
Biased expression in brain (RPKM 31.7), testis (RPKM 4.4) and 3 other tissues See more
Orthologs
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Genomic context

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See PPP2R2B in Genome Data Viewer
Location:
5q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (146580742..147081520, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (147116637..147617597, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145960305..146461083, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145826559-145827266 Neighboring gene MPRA-validated peak5524 silencer Neighboring gene transcription elongation regulator 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:145920194-145920694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:145939738-145940393 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene G protein-coupled receptor 151 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145989281-145989921 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene RNA, 7SL, cytoplasmic 791, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:146111026-146112225 Neighboring gene uncharacterized LOC107986461 Neighboring gene keratin 8 pseudogene 48 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:146168291-146168992 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:146176260-146177054 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:146196483-146197009 Neighboring gene MPRA-validated peak5525 silencer Neighboring gene protein phosphatase 2 regulatory subunit Bbeta repeat instability region Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23362 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:146473503-146474702 Neighboring gene STK32A antisense RNA 1 Neighboring gene serine/threonine kinase 32A Neighboring gene dihydropyrimidinase like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases. Madera-Salcedo IK, et al. JCI Insight, 2019 Jul 23. PMID 31335320, Free PMC Article
  2. Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma. Ishibashi K, et al. Cancer Genomics Proteomics, 2018 Jan-Feb. PMID 29275362, Free PMC Article
  3. Clinical behaviour of spinocerebellar ataxia type 12 and intermediate length abnormal CAG repeats in PPP2R2B. Srivastava AK, et al. Brain, 2017 Jan. PMID 27864267
  4. Inactivation of protein-phosphatase 2A causing hyperphosphorylation of autoantigenic paraprotein targets in MGUS/MM is due to an exchange of its regulatory subunits. Preuss KD, et al. Int J Cancer, 2014 Nov 1. PMID 24676687
  5. Differential autophagic cell death under stress with ectopic cytoplasmic and mitochondrial-specific PPP2R2B in human neuroblastoma cells. Fang K, et al. Apoptosis, 2013 May. PMID 23381641

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway.
    Title: Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway.
  2. Systematic screening identifies a 2-gene signature as a high-potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma.
    Title: Systematic screening identifies a 2-gene signature as a high-potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma.
  3. EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy.
    Title: EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy.
  4. Transcriptional regulation of PPP2R2B (B55ss), a molecule necessary for the termination of the immune response, in patients with autoimmune diseases. PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.
    Title: PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.
  5. CDK1-counteracting phosphatases PP1 and PP2A-B55, together with Aurora and Polo kinases, contribute to the temporal regulation and order of events in the different stages of mitotic exit from anaphase to cytokinesis. (Review)
    Title: Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A.
  6. Dephosphorylation and total levels of beta-catenin were dependent on PR55beta in an adenoid cystic carcinoma tumor cell line.
    Title: Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma.
  7. New pathogenic threshold of PPP2R2B CAG-43 to be pathogenic for SCA12 diagnosis.
    Title: Clinical behaviour of spinocerebellar ataxia type 12 and intermediate length abnormal CAG repeats in PPP2R2B.
  8. CAG triplet repeat expansion has been found in untranslated region of SCA12 gene in Indian spinocerebellar ataxia 12 patients.
    Title: Exploration of CAG triplet repeat in nontranslated region of SCA12 gene.
  9. Thus, Fcp1 coordinates Cdk1 and Gwl inactivation to derepress PP2A-B55, generating a dephosphorylation switch that drives mitosis progression.
    Title: Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression.
  10. investigated CAG copies within PPP2R2B in 29 patients with spinocerebellar ataxia who are excluded from the most common subtypes; 3 patients carried 53, 46 and 54 CAG repeats respectively, while the other 26 cases harbored CAG repeats less than 30
    Title: Identification of 46 CAG repeats within PPP2R2B as probably the shortest pathogenic allele for SCA12.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spinocerebellar ataxia type 12
MedGen: C1858501 OMIM: 604326 GeneReviews: Hereditary Ataxia Overview
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EBI GWAS Catalog

Description
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
EBI GWAS Catalog
Genome-wide association study of alcohol dependence.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ95686, MGC24888

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Names
protein phosphatase 2, regulatory subunit B, beta
NP_001258828.1
NP_001258829.1
NP_001258877.1
NP_858060.2
NP_858061.3
NP_858062.1
NP_858063.1
NP_858064.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011570.3 RefSeqGene

    Range
    207763..505778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001271899.1 → NP_001258828.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform g

    See identical proteins and their annotated locations for NP_001258828.1

    Status: REVIEWED

    Source sequence(s)
    AI621232, AK295347, BC031790, BX464346
    Consensus CDS
    CCDS64282.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000421396.1, ENST00000504198.5
    Conserved Domains (2) summary
    COG5170
    Location:14 → 444
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:33 → 81
    7WD40; WD40 repeat [structural motif]

  2. NM_001271900.2 → NP_001258829.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform f

    See identical proteins and their annotated locations for NP_001258829.1

    Status: REVIEWED

    Source sequence(s)
    AC008728, AC009186, AC010251, AC011386
    Consensus CDS
    CCDS64281.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000377935.4, ENST00000394413.7
    Conserved Domains (2) summary
    COG5170
    Location:80 → 496
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:85 → 133
    7WD40; WD40 repeat [structural motif]

  3. NM_001271948.2 → NP_001258877.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform d

    See identical proteins and their annotated locations for NP_001258877.1

    Status: REVIEWED

    Source sequence(s)
    AC008728, AI621232, AK314810, BC031790, BP195204
    Consensus CDS
    CCDS43380.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000398779.2, ENST00000453001.5
    Conserved Domains (2) summary
    COG5170
    Location:13 → 427
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:16 → 64
    7WD40; WD40 repeat [structural motif]

  4. NM_001428277.1 → NP_001415206.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform e

    Status: REVIEWED

    Source sequence(s)
    AC008728, AC009186, AC011386
    UniProtKB/Swiss-Prot
    A6NEJ2, A8K102, B3KPD0, B7Z2F2, B7Z304, D3DQF7, D3DQF8, G3V149, Q00005

  5. NM_001428279.1 → NP_001415208.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform e

    Status: REVIEWED

    Source sequence(s)
    AC008728, AC009186, AC011386
    UniProtKB/Swiss-Prot
    A6NEJ2, A8K102, B3KPD0, B7Z2F2, B7Z304, D3DQF7, D3DQF8, G3V149, Q00005

  6. NM_181674.3 → NP_858060.2  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform a

    See identical proteins and their annotated locations for NP_858060.2

    Status: REVIEWED

    Source sequence(s)
    AC008728, AI621232, BC031790, DA522334
    Consensus CDS
    CCDS4284.2
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000377936.1, ENST00000394414.5
    Conserved Domains (2) summary
    COG5170
    Location:88 → 504
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:93 → 141
    7WD40; WD40 repeat [structural motif]

  7. NM_181675.4 → NP_858061.3  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform e

    Status: REVIEWED

    Source sequence(s)
    AC008728, AC009186, AC011386
    Consensus CDS
    CCDS93800.1
    UniProtKB/Swiss-Prot
    A6NEJ2, A8K102, B3KPD0, B7Z2F2, B7Z304, D3DQF7, D3DQF8, G3V149, Q00005
    Related
    ENSP00000377933.3, ENST00000394411.9
    Conserved Domains (2) summary
    COG5170
    Location:22 → 438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 75
    7WD40; WD40 repeat [structural motif]

  8. NM_181676.3 → NP_858062.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform b

    See identical proteins and their annotated locations for NP_858062.1

    Status: REVIEWED

    Source sequence(s)
    AC008728, AI621232, BC031790, DA522334
    Consensus CDS
    CCDS4283.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000336591.6, ENST00000336640.10
    Conserved Domains (2) summary
    COG5170
    Location:25 → 441
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:30 → 78
    7WD40; WD40 repeat [structural motif]

  9. NM_181677.2 → NP_858063.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform c

    See identical proteins and their annotated locations for NP_858063.1

    Status: REVIEWED

    Source sequence(s)
    AI621232, BC031790, DA155307, DA365141
    UniProtKB/Swiss-Prot
    Q00005
    Conserved Domains (2) summary
    COG5170
    Location:2 → 418
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:7 → 55
    7WD40; WD40 repeat [structural motif]

  10. NM_181678.2 → NP_858064.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform d

    See identical proteins and their annotated locations for NP_858064.1

    Status: REVIEWED

    Source sequence(s)
    AI621232, BC031790, BI669304, DA365141
    Consensus CDS
    CCDS43380.1
    UniProtKB/Swiss-Prot
    Q00005
    Related
    ENSP00000431320.1, ENST00000508545.6
    Conserved Domains (2) summary
    COG5170
    Location:13 → 427
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:16 → 64
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    146580742..147081520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    147116637..147617597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00005.1 GenPept UniProtKB/Swiss-Prot:Q00005

Gene LinkOut

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