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MSTO1 misato mitochondrial distribution and morphology regulator 1 [ Homo sapiens (human) ]

Gene ID: 55154, updated on 7-Apr-2024

Summary

Official Symbol
MSTO1provided by HGNC
Official Full Name
misato mitochondrial distribution and morphology regulator 1provided by HGNC
Primary source
HGNC:HGNC:29678
See related
Ensembl:ENSG00000125459 MIM:617619; AllianceGenome:HGNC:29678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST; MMYAT; LST005
Summary
Involved in mitochondrion distribution. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 18.6), fat (RPKM 12.3) and 25 other tissues See more
Orthologs
NEW
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Genomic context

Location:
1q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155563246..155614967)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154748735..154753532)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155579961..155584758)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene RNA, U6 small nuclear 1297, pseudogene Neighboring gene POU class 5 homeobox 1 pseudogene 4 Neighboring gene NANOG hESC enhancer GRCh37_chr1:155469805-155470306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155484783-155485282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155499969-155500470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155515470-155515970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1817 Neighboring gene Sharpr-MPRA regulatory region 11909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1407 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155532613-155533180 Neighboring gene Sharpr-MPRA regulatory region 7926 Neighboring gene uncharacterized LOC101929703 Neighboring gene ASH1L antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155546798-155546935 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155556739-155556902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155560641-155561220 Neighboring gene Sharpr-MPRA regulatory region 723 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:155569297-155569949 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155569950-155570603 Neighboring gene claudin 6 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155578996-155579870 Neighboring gene uncharacterized LOC105371452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155579871-155580745 Neighboring gene gon-4 like pseudogene Neighboring gene death associated protein 3 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:155604951-155605710 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155605711-155606471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155606472-155607231 Neighboring gene gon-4 like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
MedGen: C4540096 OMIM: 617675 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10504, DKFZp686B1757, DKFZp686I01261

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrion distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein misato homolog 1
Names
misato 1, mitochondrial distribution and morphology regulator
misato homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256532.1NP_001243461.1  protein misato homolog 1 isoform b

    See identical proteins and their annotated locations for NP_001243461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AF272833, AK222863, BC002535, DA807092
    UniProtKB/TrEMBL
    A8K3J5
    Conserved Domains (1) summary
    cd06060
    Location:6562
    misato; Misato segment II tubulin-like domain
  2. NM_001256533.1NP_001243462.1  protein misato homolog 1 isoform c

    See identical proteins and their annotated locations for NP_001243462.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AF272833, BC002535, CR749791, DA807092
    UniProtKB/TrEMBL
    A8K3J5
    Conserved Domains (1) summary
    cd06060
    Location:6551
    misato; Misato segment II tubulin-like domain
  3. NM_001350772.1NP_001337701.1  protein misato homolog 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF272833, BC002535, CR749791, DA807092
    UniProtKB/TrEMBL
    A8K3J5
    Related
    ENSP00000357325.4, ENST00000368341.8
    Conserved Domains (1) summary
    cd06060
    Location:6552
    misato; Misato segment II tubulin-like domain
  4. NM_001350773.1NP_001337702.1  protein misato homolog 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BE717044, DA807092
    Conserved Domains (1) summary
    cd06060
    Location:6428
    misato; Misato segment II tubulin-like domain
  5. NM_001350774.1NP_001337703.1  protein misato homolog 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BE717044, DA807092
    Consensus CDS
    CCDS91070.1
    UniProtKB/TrEMBL
    A0A3B3IUD2
    Related
    ENSP00000498188.1, ENST00000649846.1
    Conserved Domains (1) summary
    cd06060
    Location:6428
    misato; Misato segment II tubulin-like domain
  6. NM_001350775.1NP_001337704.1  protein misato homolog 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, BX421996, DA807092, H12094
    UniProtKB/TrEMBL
    A8K3J5
    Conserved Domains (1) summary
    cd06060
    Location:6511
    misato; Misato segment II tubulin-like domain
  7. NM_001350776.1NP_001337705.1  protein misato homolog 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, BF027217, DA070565, DA807092
    UniProtKB/TrEMBL
    B4DLS9
    Conserved Domains (1) summary
    cd06060
    Location:88508
    misato; Misato segment II tubulin-like domain
  8. NM_001350777.1NP_001337706.1  protein misato homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BX421996, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:11386
    misato; Misato segment II tubulin-like domain
  9. NM_001350778.1NP_001337707.1  protein misato homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BX421996, DA272145, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:11386
    misato; Misato segment II tubulin-like domain
  10. NM_001350779.1NP_001337708.1  protein misato homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BX421996, DA379275, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:11386
    misato; Misato segment II tubulin-like domain
  11. NM_001350780.1NP_001337709.1  protein misato homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA070565, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  12. NM_001350781.1NP_001337710.1  protein misato homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, AY334564, BC002535, DA070565, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  13. NM_001350782.1NP_001337711.1  protein misato homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Related
    ENSP00000513434.1, ENST00000697770.1
    Conserved Domains (1) summary
    cd06060
    Location:1385
    misato; Misato segment II tubulin-like domain
  14. NM_001350783.1NP_001337712.1  protein misato homolog 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:1384
    misato; Misato segment II tubulin-like domain
  15. NM_001350784.1NP_001337713.1  protein misato homolog 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA379275, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:7382
    misato; Misato segment II tubulin-like domain
  16. NM_001350785.1NP_001337714.1  protein misato homolog 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, AY334564, BC002535, DA272145, DA379275, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:7382
    misato; Misato segment II tubulin-like domain
  17. NM_001350786.1NP_001337715.1  protein misato homolog 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, BE717044, DA070565, DA272145, DA807092
    Conserved Domains (1) summary
    cl10017
    Location:1250
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  18. NM_001350787.1NP_001337716.1  protein misato homolog 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, CR749791, DA379275, DA807092
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:7371
    misato; Misato segment II tubulin-like domain
  19. NM_001350788.1NP_001337717.1  protein misato homolog 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cd06060
    Location:1333
    misato; Misato segment II tubulin-like domain
  20. NM_001350789.1NP_001337718.1  protein misato homolog 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
    UniProtKB/TrEMBL
    A0A8V8TLP0
    Conserved Domains (1) summary
    cl10017
    Location:7330
    Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
  21. NM_018116.4NP_060586.2  protein misato homolog 1 isoform a

    See identical proteins and their annotated locations for NP_060586.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF272833, AK001366, AK222863, BX537684
    Consensus CDS
    CCDS1114.1
    UniProtKB/Swiss-Prot
    Q53GR8, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9BUK6, Q9NQX2, Q9NVU4
    UniProtKB/TrEMBL
    A8K3J5
    Related
    ENSP00000245564.3, ENST00000245564.8
    Conserved Domains (1) summary
    cd06060
    Location:6563
    misato; Misato segment II tubulin-like domain

RNA

  1. NR_046292.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK001366, AK297140, AK309573, AL353807, BC002535, DA807092
  2. NR_046293.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK001366, AK309573, BC002535, DA807092
  3. NR_046294.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK056128, DA807092
    Related
    ENST00000494995.5
  4. NR_046295.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF272833, AK001366, BC002535, BX537684, DA807092
    Related
    ENST00000490743.5
  5. NR_146907.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, BC002535, DA807092
  6. NR_146908.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AF272833, AK001366, AL353807, BC002535, BX421996, DA807092

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    155563246..155614967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424007.1XP_047279963.1  protein misato homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q53GR8, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9BUK6, Q9NQX2, Q9NVU4
  2. XM_047424008.1XP_047279964.1  protein misato homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q53GR8, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9BUK6, Q9NQX2, Q9NVU4
  3. XM_047424021.1XP_047279977.1  protein misato homolog 1 isoform X3

  4. XM_047424030.1XP_047279986.1  protein misato homolog 1 isoform X4

  5. XM_047424011.1XP_047279967.1  protein misato homolog 1 isoform X2

    Related
    ENST00000483734.5
  6. XM_047424040.1XP_047279996.1  protein misato homolog 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154748735..154753532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337366.1XP_054193341.1  protein misato homolog 1 isoform X3

  2. XM_054337372.1XP_054193347.1  protein misato homolog 1 isoform X4

  3. XM_054337364.1XP_054193339.1  protein misato homolog 1 isoform X2

  4. XM_054337371.1XP_054193346.1  protein misato homolog 1 isoform X15

  5. XM_054337368.1XP_054193343.1  protein misato homolog 1 isoform X12

  6. XM_054337369.1XP_054193344.1  protein misato homolog 1 isoform X13

  7. XM_054337370.1XP_054193345.1  protein misato homolog 1 isoform X14

  8. XM_054337360.1XP_054193335.1  protein misato homolog 1 isoform X6

  9. XM_054337361.1XP_054193336.1  protein misato homolog 1 isoform X7

  10. XM_054337362.1XP_054193337.1  protein misato homolog 1 isoform X8

  11. XM_054337367.1XP_054193342.1  protein misato homolog 1 isoform X11

  12. XM_054337363.1XP_054193338.1  protein misato homolog 1 isoform X9

  13. XM_054337365.1XP_054193340.1  protein misato homolog 1 isoform X10

  14. XM_054337374.1XP_054193349.1  protein misato homolog 1 isoform X16

  15. XM_054337373.1XP_054193348.1  protein misato homolog 1 isoform X5