U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HAUS2 HAUS augmin like complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 55142, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
HAUS2provided by HGNC
Official Full Name
HAUS augmin like complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:25530
See related
Ensembl:ENSG00000137814 MIM:613429; AllianceGenome:HGNC:25530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEP27; C15orf25; HsT17025
Summary
The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 7.1), brain (RPKM 3.8) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HAUS2 in Genome Data Viewer
Location:
15q15.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (42548838..42569994)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40354888..40377004)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42841036..42862192)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 106 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:42749529-42750361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42750362-42751193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9303 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42787505-42788048 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:42788049-42788592 Neighboring gene synaptosome associated protein 23 Neighboring gene MPRA-validated peak2311 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9304 Neighboring gene leucine rich repeat containing 57 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9305 Neighboring gene eukaryotic translation initiation factor 4E binding protein 2 pseudogene 2 Neighboring gene MYL12B pseudogene 1 Neighboring gene StAR related lipid transfer domain containing 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10460

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule nucleation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HAUS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HAUS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in mitotic spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
HAUS augmin-like complex subunit 2
Names
centrosomal protein 27kDa
centrosomal protein of 27 kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130447.2 → NP_001123919.1  HAUS augmin-like complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001123919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, segment in the CDS, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC018362, AI368236, DA923763, DB450370
    Consensus CDS
    CCDS45247.1
    UniProtKB/Swiss-Prot
    Q9NVX0
    Related
    ENSP00000456578.1, ENST00000568876.5
    Conserved Domains (1) summary
    pfam15003
    Location:8 → 159
    HAUS2; HAUS augmin-like complex subunit 2

  2. NM_001323629.2 → NP_001310558.1  HAUS augmin-like complex subunit 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018362
    Consensus CDS
    CCDS81867.1
    UniProtKB/TrEMBL
    H3BP16
    Related
    ENSP00000455104.1, ENST00000564279.5

  3. NM_001323630.2 → NP_001310559.1  HAUS augmin-like complex subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC018362
    Conserved Domains (1) summary
    pfam15003
    Location:1 → 59
    HAUS2; HAUS augmin-like complex subunit 2

  4. NM_001323631.2 → NP_001310560.1  HAUS augmin-like complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC018362
    Conserved Domains (1) summary
    pfam15003
    Location:1 → 96
    HAUS2; HAUS augmin-like complex subunit 2

  5. NM_001323632.2 → NP_001310561.1  HAUS augmin-like complex subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC018362
    Conserved Domains (1) summary
    pfam15003
    Location:1 → 96
    HAUS2; HAUS augmin-like complex subunit 2

  6. NM_018097.3 → NP_060567.1  HAUS augmin-like complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_060567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC018362, AI368236, BC010903
    Consensus CDS
    CCDS10090.1
    UniProtKB/Swiss-Prot
    C9JH36, Q9H9B3, Q9NVX0
    Related
    ENSP00000260372.3, ENST00000260372.8
    Conserved Domains (1) summary
    pfam15003
    Location:8 → 190
    HAUS2; HAUS augmin-like complex subunit 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    42548838..42569994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022397.2 → XP_016877886.1  HAUS augmin-like complex subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam15003
    Location:1 → 96
    HAUS2; HAUS augmin-like complex subunit 2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    40354888..40377004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378357.1 → XP_054234332.1  HAUS augmin-like complex subunit 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NVX0.1 GenPept UniProtKB/Swiss-Prot:Q9NVX0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous