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MED9 mediator complex subunit 9 [ Homo sapiens (human) ]

Gene ID: 55090, updated on 11-Apr-2024

Summary

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Official Symbol
MED9provided by HGNC
Official Full Name
mediator complex subunit 9provided by HGNC
Primary source
HGNC:HGNC:25487
See related
Ensembl:ENSG00000141026 MIM:609878; AllianceGenome:HGNC:25487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MED25
Summary
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 9.0), brain (RPKM 7.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17p11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (17477000..17493221)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (17423576..17439799)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17380314..17396535)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak2757 silencer Neighboring gene ligand of numb-protein X 1, E3 ubiquitin protein ligase pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17345077-17345922 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:17349107-17350306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17353405-17353906 Neighboring gene tRNA splicing endonuclease subunit 15 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8243 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17406686-17407658 Neighboring gene ras related dexamethasone induced 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17416043-17416912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17416913-17417782 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:17418653-17419522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17420393-17421262 Neighboring gene phosphatidylethanolamine N-methyltransferase Neighboring gene VISTA enhancer hs1917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17448679-17449178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17456297-17457102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17465957-17466820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17470469-17471358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17471359-17472250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17472251-17473140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:17479915-17480660 Neighboring gene RNA, U6 small nuclear 468, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNA-Seq for the identification of novel Mediator transcripts in endothelial progenitor cells. Rienzo M, et al. Gene, 2014 Aug 15. PMID 24952135
  2. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Donner AJ, et al. Nat Struct Mol Biol, 2010 Feb. PMID 20098423, Free PMC Article
  3. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. Bi W, et al. Genome Res, 2002 May. PMID 11997338, Free PMC Article
  4. The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Davis MA, et al. Genes Dev, 2013 Jan 15. PMID 23322298, Free PMC Article
  5. The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Han SJ, et al. Mol Pharmacol, 2016 Jan. PMID 26487511, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification.
    Title: Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification.
  2. the FLJ10193 protein, which we designate Med25, is a bona fide subunit of the mammalian Mediator complex
    Title: A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10193, MGC138234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 9
Names
mediator of RNA polymerase II transcription, subunit 9 homolog
mediator subunit 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018019.3 → NP_060489.1  mediator of RNA polymerase II transcription subunit 9

    See identical proteins and their annotated locations for NP_060489.1

    Status: REVIEWED

    Source sequence(s)
    AC073621
    Consensus CDS
    CCDS11184.1
    UniProtKB/Swiss-Prot
    Q9NWA0
    Related
    ENSP00000268711.3, ENST00000268711.4
    Conserved Domains (1) summary
    pfam07544
    Location:64 → 139
    Med9; RNA polymerase II transcription mediator complex subunit 9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    17477000..17493221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    17423576..17439799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NWA0.1 GenPept UniProtKB/Swiss-Prot:Q9NWA0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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