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entpd6 ectonucleoside triphosphate diphosphohydrolase 6 [ Danio rerio (zebrafish) ]

Gene ID: 550560, updated on 2-Nov-2024

Summary

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Official Symbol
entpd6provided by ZNC
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-412
See related
Ensembl:ENSDARG00000008757 AllianceGenome:ZFIN:ZDB-GENE-050417-412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110701
Summary
Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to be active in Golgi apparatus and membrane. Is expressed in brain; heart; and liver. Orthologous to human ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See entpd6 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (21102306..21123990)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (21082452..21104154)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2D 1a Neighboring gene visual system homeobox 1 homolog, chx10-like Neighboring gene phosphorylase, glycogen; brain Neighboring gene abhydrolase domain containing 12, lysophospholipase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies. Tsai IC, et al. JCI Insight, 2019 Nov 14. PMID 31723061, Free PMC Article
  2. NTPDase family in zebrafish: Nucleotide hydrolysis, molecular identification and gene expression profiles in brain, liver and heart. Rosemberg DB, et al. Comp Biochem Physiol B Biochem Mol Biol, 2010 Mar. PMID 19922813
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 6
Names
NTPDase6
ectonucleoside triphosphate diphosphohydrolase 6 (putative function)
ectonucleoside triphosphate diphosphohydrolase 6 (putative)
NP_001017862.1
XP_009291247.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017862.1 → NP_001017862.1  ectonucleoside triphosphate diphosphohydrolase 6

    See identical proteins and their annotated locations for NP_001017862.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092988
    UniProtKB/TrEMBL
    Q567W7
    Related
    ENSDARP00000037620.6, ENSDART00000035432.7
    Conserved Domains (1) summary
    cl17037
    Location:56 → 429
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    21102306..21123990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292972.4 → XP_009291247.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AR88
    Conserved Domains (1) summary
    cl17037
    Location:56 → 428
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394984.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    176029..198120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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