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ppp3cb protein phosphatase 3, catalytic subunit, beta isozyme [ Danio rerio (zebrafish) ]

Gene ID: 550554, updated on 2-Nov-2024

Summary

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Official Symbol
ppp3cbprovided by ZNC
Official Full Name
protein phosphatase 3, catalytic subunit, beta isozymeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-406
See related
Ensembl:ENSDARG00000025106 AllianceGenome:ZFIN:ZDB-GENE-050417-406
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fq19c08; zgc:110141
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade. Predicted to act upstream of or within calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Predicted to be active in cytosol. Is expressed in hatching gland; integument; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ppp3cb in Genome Data Viewer
Location:
chromosome: 14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7789093..7891682, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (7482684..7585328, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-39i2.2 Neighboring gene stimulator of interferon response cGAMP interactor 1 Neighboring gene ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) Neighboring gene zgc:110843

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cabin1 expression suggests roles in neuronal development. Hammond DR, et al. Dev Dyn, 2010 Sep. PMID 20652955
  2. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcineurin-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
NP_001017856.1
XP_009305997.1
XP_009305999.1
XP_021336694.1
XP_068069308.1
XP_068069309.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017856.1 → NP_001017856.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

    See identical proteins and their annotated locations for NP_001017856.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092753
    UniProtKB/TrEMBL
    Q568R4
    Related
    ENSDARP00000032726.7, ENSDART00000029981.8
    Conserved Domains (2) summary
    smart00156
    Location:49 → 318
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:30 → 334
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    7789093..7891682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213208.1 → XP_068069309.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

  2. XM_021481019.2 → XP_021336694.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

    UniProtKB/TrEMBL
    A0A8M9QGE2
    Conserved Domains (1) summary
    cd07416
    Location:29 → 333
    MPP_PP2B; PP2B, metallophosphatase domain

  3. XM_009307724.4 → XP_009305999.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

    UniProtKB/TrEMBL
    A0A8M3AZJ8
    Conserved Domains (2) summary
    smart00156
    Location:60 → 329
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:41 → 345
    MPP_PP2B; PP2B, metallophosphatase domain

  4. XM_009307722.4 → XP_009305997.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A8M3BEY4
    Conserved Domains (2) summary
    smart00156
    Location:60 → 329
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:41 → 345
    MPP_PP2B; PP2B, metallophosphatase domain

  5. XM_068213207.1 → XP_068069308.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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