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mecr mitochondrial trans-2-enoyl-CoA reductase [ Danio rerio (zebrafish) ]

Gene ID: 550550, updated on 17-Sep-2024

Summary

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Official Symbol
mecrprovided by ZNC
Official Full Name
mitochondrial trans-2-enoyl-CoA reductaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-399
See related
Ensembl:ENSDARG00000032326 AllianceGenome:ZFIN:ZDB-GENE-050417-399
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110153
Summary
Predicted to enable trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mecr in Genome Data Viewer
Location:
chromosome: 16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4695086..4707671)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (4864875..4878382)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily T, polypeptide 8 Neighboring gene lin-28 homolog Aa Neighboring gene sphingomyelin phosphodiesterase acid like 3B Neighboring gene thymocyte selection associated family member 2 Neighboring gene replication protein A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
enoyl-[acyl-carrier-protein] reductase, mitochondrial
Names
2-enoyl thioester reductase
trans-2-enoyl-CoA reductase, mitochondrial
NP_001017852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017852.1 → NP_001017852.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001017852.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092759
    UniProtKB/Swiss-Prot
    Q6GQN8
    UniProtKB/TrEMBL
    Q568Q9
    Related
    ENSDARP00000038801.6, ENSDART00000039054.8
    Conserved Domains (2) summary
    cd08290
    Location:45 → 377
    ETR; 2-enoyl thioester reductase (ETR)
    COG0604
    Location:46 → 366
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    4695086..4707671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GQN8.2 GenPept UniProtKB/Swiss-Prot:Q6GQN8

Gene LinkOut

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