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gabra4 gamma-aminobutyric acid type A receptor subunit alpha4 [ Danio rerio (zebrafish) ]

Gene ID: 550520, updated on 28-Oct-2024

Summary

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Official Symbol
gabra4provided by ZNC
Official Full Name
gamma-aminobutyric acid type A receptor subunit alpha4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-360
See related
Ensembl:ENSDARG00000013389 AllianceGenome:ZFIN:ZDB-GENE-050417-360
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110204
Summary
Predicted to enable GABA-gated chloride ion channel activity. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in dendrite membrane and postsynapse. Is expressed in brain; eye; neurons; otic vesicle; and spinal cord. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See gabra4 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (4610419..4682114, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (4339778..4378320, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene GTP binding elongation factor GUF1 Neighboring gene gamma-aminobutyric acid receptor subunit alpha-2 Neighboring gene transfer RNA serine (anticodon CGA) Neighboring gene adaptor related protein complex 1 associated regulatory protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. GABAA α subunit control of hyperactive behavior in developing zebrafish. Barnaby W, et al. Genetics, 2022 Apr 4. PMID 35106556, Free PMC Article
  2. Abnormal expression of GABA(A) receptor subunits and hypomotility upon loss of gabra1 in zebrafish. Reyes-Nava NG, et al. Biol Open, 2020 Apr 13. PMID 32205311, Free PMC Article
  3. Methylenetetrahydrofolate reductase deficiency and high-dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish. Simonian R, et al. Hum Mol Genet, 2023 Apr 20. PMID 36637428, Free PMC Article
  4. Abamectin induces rapid and reversible hypoactivity within early zebrafish embryos. Raftery TD, et al. Neurotoxicol Teratol, 2015 May-Jun. PMID 25733401
  5. GABA(A) receptor-mediated seizure liabilities: a mixed-methods screening approach. Bampali K, et al. Cell Biol Toxicol, 2023 Dec. PMID 37093397, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GABAA alpha subunit control of hyperactive behavior in developing zebrafish.
    Title: GABAA α subunit control of hyperactive behavior in developing zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables GABA-gated chloride ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to benzodiazepine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit alpha-4
Names
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017822.1 → NP_001017822.1  gamma-aminobutyric acid receptor subunit alpha-4 precursor

    See identical proteins and their annotated locations for NP_001017822.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092794
    UniProtKB/TrEMBL
    A0A8N7XJ93, B2GQ32, F1RB35, Q568M9
    Related
    ENSDARP00000005716.8, ENSDART00000014454.8
    Conserved Domains (2) summary
    pfam02931
    Location:49 → 256
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:263 → 543
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    4610419..4682114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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