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ctsk cathepsin K [ Danio rerio (zebrafish) ]

Gene ID: 550475, updated on 28-Oct-2024

Summary

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Official Symbol
ctskprovided by ZNC
Official Full Name
cathepsin Kprovided by ZNC
Primary source
ZFIN:ZDB-GENE-001205-4
See related
Ensembl:ENSDARG00000040251 AllianceGenome:ZFIN:ZDB-GENE-001205-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa95f03; wu:fb08b05; zgc:110367
Summary
Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Acts upstream of or within bone morphogenesis; cartilage development; and response to mechanical stimulus. Predicted to be located in plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including cardiovascular system; head; lateral line system; mesoderm; and pectoral fin. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See ctsk in Genome Data Viewer
Location:
chromosome: 16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (29492994..29502549)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (29558371..29567926)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch211-113g11.6 Neighboring gene uncharacterized LOC137487914 Neighboring gene leucine rich repeat and Ig domain containing 4b Neighboring gene cathepsin S, ortholog2, tandem duplicate 1 Neighboring gene cathepsin S, ortholog 2, tandem duplicate 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation. Kim HM, et al. Bone, 2020 Feb. PMID 31730830
  2. 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease. Kague E, et al. Bone Res, 2021 Aug 31. PMID 34465741, Free PMC Article
  3. Laser-mediated osteoblast ablation triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish. Geurtzen K, et al. Development, 2022 Apr 15. PMID 35485304
  4. An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Parichy DM, et al. Development, 2000 Jul. PMID 10862741
  5. Clinical pathologies of bone fracture modelled in zebrafish. Tomecka MJ, et al. Dis Model Mech, 2019 Sep 3. PMID 31383797, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation.
    Title: Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation.
  2. components of the large latent TGFss complex were identified as novel targets of cathepsin K at neutral pH.
    Title: Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to mechanical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cathepsin K
Names
etID33526.16
NP_001017778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017778.1 → NP_001017778.1  cathepsin K precursor

    See identical proteins and their annotated locations for NP_001017778.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092901
    UniProtKB/TrEMBL
    Q568D6
    Related
    ENSDARP00000007535.7, ENSDART00000011497.8
    Conserved Domains (2) summary
    smart00848
    Location:30 → 89
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:118 → 332
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    29492994..29502549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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