cops6 COP9 signalosome subunit 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cops6provided by ZNC
Official Full Name: COP9 signalosome subunit 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-289
See related: AllianceGenome:ZFIN:ZDB-GENE-050417-289
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112075
Summary: Predicted to enable isopeptidase activity and metallopeptidase activity. Acts upstream of or within several processes, including central nervous system development; convergent extension; and cranial skeletal system development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS6 (COP9 signalosome subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003335249.1 (2358..3524)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003335249.1 (2358..3524)

NW_003335249.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings indicate that cops6 plays an anti-apoptotic role during segmentation.
Title: The deubiquitylating enzyme Cops6 regulates different developmental processes during early zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

G47788 (e-PCR)
- UniSTS:108557

G46836 (e-PCR)
- UniSTS:107632

fb16c06.y1 (e-PCR)
- UniSTS:190186

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein deneddylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: COP9 signalosome complex subunit 6

Names: COP9 constitutive photomorphogenic homolog subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017768.1 → NP_001017768.1 COP9 signalosome complex subunit 6

See identical proteins and their annotated locations for NP_001017768.1

Status: PROVISIONAL

Source sequence(s)

BC093188

UniProtKB/TrEMBL

Q567F8

Conserved Domains (1) summary

cd08063
Location:9 → 291

MPN_CSN6; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6