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b4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [ Danio rerio (zebrafish) ]

Gene ID: 550425, updated on 17-Aug-2024

Summary

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Official Symbol
b4galt1provided by ZNC
Official Full Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-236
See related
AllianceGenome:ZFIN:ZDB-GENE-050417-236
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:111810
Summary
Enables galactosyltransferase activity. Acts upstream of or within cell migration involved in gastrulation and notochord morphogenesis. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in lateral mesoderm; olfactory placode; oocyte; and optic vesicle. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to human B4GALT1 (beta-1,4-galactosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (12141467..12161147, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11454667..11474347, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene microsomal triglyceride transfer protein Neighboring gene serine peptidase inhibitor, Kazal type 4 Neighboring gene STRA6-like Neighboring gene tudor domain containing 7 a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of natural human β1,4-GalT1 variants and of non-mammalian homologues in plants leads to differences in galactosylation of N-glycans. Hesselink T, et al. Transgenic Res, 2014 Oct. PMID 25082356
  2. An image-based data-driven analysis of cellular architecture in a developing tissue. Hartmann J, et al. Elife, 2020 Jun 5. PMID 32501214, Free PMC Article
  3. A beta1,4-galactosyltransferase is required for convergent extension movements in zebrafish. Machingo QJ, et al. Dev Biol, 2006 Sep 15. PMID 16904099
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 1
NP_001017730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017730.1 → NP_001017730.1  beta-1,4-galactosyltransferase 1

    See identical proteins and their annotated locations for NP_001017730.1

    Status: PROVISIONAL

    Source sequence(s)
    BC093107
    UniProtKB/TrEMBL
    Q567N4
    Conserved Domains (1) summary
    pfam13733
    Location:97 → 191
    Glyco_transf_7N; N-terminal region of glycosyl transferase group 7

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    12141467..12161147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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