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alad aminolevulinate dehydratase [ Danio rerio (zebrafish) ]

Gene ID: 550338, updated on 2-Nov-2024

Summary

Official Symbol
aladprovided by ZNC
Official Full Name
aminolevulinate dehydrataseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-123
See related
Ensembl:ENSDARG00000100372 AllianceGenome:ZFIN:ZDB-GENE-050417-123
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:110219; CH73-203I15.1
Summary
Predicted to enable porphobilinogen synthase activity and zinc ion binding activity. Predicted to be involved in heme biosynthetic process. Predicted to act upstream of or within porphyrin-containing compound biosynthetic process. Predicted to be active in cytosol. Is expressed in blood and ventral mesoderm. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See alad in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (54482976..54497040, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (53836383..53850447, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene uncharacterized LOC101882650 Neighboring gene transmembrane protein 203 Neighboring gene taperin

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables porphobilinogen synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables porphobilinogen synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
delta-aminolevulinic acid dehydratase
NP_001017645.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017645.1NP_001017645.1  delta-aminolevulinic acid dehydratase

    See identical proteins and their annotated locations for NP_001017645.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092804
    UniProtKB/TrEMBL
    Q568L9
    Related
    ENSDARP00000136768.1, ENSDART00000160492.2
    Conserved Domains (1) summary
    cd04824
    Location:10329
    eu_ALAD_PBGS_cysteine_rich; Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    54482976..54497040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)