spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: spsb3provided by Xenbase
Official Full Name: splA/ryanodine receptor domain and SOCS box containing 3provided by Xenbase
Primary source: Xenbase:XB-GENE-971062
See related: Ensembl:ENSXETG00000010355 AllianceGenome:Xenbase:XB-GENE-971062
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	9	NC_030685.2 (21431010..21444511)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	9	NC_030685.1 (15565898..15575194)

Chromosome 9 - NC_030685.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cGAS/STING signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SPRY domain-containing SOCS box protein 3

Names: SSB-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017350.2 → NP_001017350.1 SPRY domain-containing SOCS box protein 3

See identical proteins and their annotated locations for NP_001017350.1

Status: PROVISIONAL

Source sequence(s)

CR848600

UniProtKB/Swiss-Prot

Q28DT9

UniProtKB/TrEMBL

A0A803K9Z5, B1H148

Related

ENSXETP00000117160.1, ENSXETT00000120603.1

Conserved Domains (2) summary

cd12876
Location:104 → 286

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:276 → 309

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

21431010..21444511

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012970484.3 → XP_012825938.1 SPRY domain-containing SOCS box protein 3 isoform X1

See identical proteins and their annotated locations for XP_012825938.1

UniProtKB/Swiss-Prot

Q28DT9

UniProtKB/TrEMBL

A0A803K9Z5, B1H148

Conserved Domains (2) summary

cd12876
Location:104 → 286

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:276 → 309

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_031892698.1 → XP_031748558.1 SPRY domain-containing SOCS box protein 3 isoform X1

UniProtKB/Swiss-Prot

Q28DT9

UniProtKB/TrEMBL

A0A803K9Z5, B1H148

Conserved Domains (2) summary

cd12876
Location:104 → 286

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:276 → 309

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_012970482.3 → XP_012825936.1 SPRY domain-containing SOCS box protein 3 isoform X1

See identical proteins and their annotated locations for XP_012825936.1

UniProtKB/Swiss-Prot

Q28DT9

UniProtKB/TrEMBL

A0A803K9Z5, B1H148

Related

ENSXETP00000022767.3, ENSXETT00000022767.5

Conserved Domains (2) summary

cd12876
Location:104 → 286

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:276 → 309

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_012970483.3 → XP_012825937.1 SPRY domain-containing SOCS box protein 3 isoform X1

See identical proteins and their annotated locations for XP_012825937.1

UniProtKB/Swiss-Prot

Q28DT9

UniProtKB/TrEMBL

A0A803K9Z5, B1H148

Conserved Domains (2) summary

cd12876
Location:104 → 286

SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family

cl02533
Location:276 → 309

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...