ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: ezh2provided by Xenbase
Official Full Name: enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by Xenbase
Primary source: Xenbase:XB-GENE-956215
See related: Ensembl:ENSXETG00000020146 AllianceGenome:Xenbase:XB-GENE-956215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: xez; enx1; ezh1; kmt6; enx-1; ezh2-a; ezh2-b; xtezh2
Summary: Predicted to enable histone H3K27 methyltransferase activity and promoter-specific chromatin binding activity. Predicted to be involved in heterochromatin formation. Predicted to act upstream of or within negative regulation of gene expression, epigenetic. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Is expressed in musculoskeletal system; nervous system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (55125040..55172583)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (63741966..63788780)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that at the blastula stage, jmjd3, utx and ezh2 showed similar expression patterns in the animal cap and marginal zone that give rise to the ectoderm and mesoderm, respectively.
Title: Comparative expression analysis of the H3K27 demethylases, JMJD3 and UTX, with the H3K27 methylase, EZH2, in Xenopus.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase EZH2

Names: Polycomb protein EZH2; enhancer of zeste homolog 2

NP_001017293.1

EC 2.1.1.356

XP_012820250.1

EC 2.1.1.356

XP_012820251.1

EC 2.1.1.356

XP_012820252.1

EC 2.1.1.356

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017293.2 → NP_001017293.1 histone-lysine N-methyltransferase EZH2

See identical proteins and their annotated locations for NP_001017293.1

Status: PROVISIONAL

Source sequence(s)

CR855647

UniProtKB/Swiss-Prot

Q28D84

UniProtKB/TrEMBL

A0A6I8SN85

Related

ENSXETP00000099537.2, ENSXETT00000081726.2

Conserved Domains (4) summary

COG2940
Location:472 → 728

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam11616
Location:39 → 67

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 251

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

cd19218
Location:611 → 730

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030682.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

55125040..55172583

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012964796.3 → XP_012820250.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

A0A6I8R1Z5, A0A6I8SN85, F6SQP1

Related

ENSXETP00000043460.5, ENSXETT00000043460.5

Conserved Domains (2) summary

smart00317
Location:635 → 756

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:54 → 82

EZH2_WD-Binding; WD repeat binding protein EZH2
XM_012964798.3 → XP_012820252.1 histone-lysine N-methyltransferase EZH2 isoform X3

UniProtKB/TrEMBL

A0A6I8S7L9, A0A6I8SN85

Related

ENSXETP00000090814.2, ENSXETT00000083324.2

Conserved Domains (4) summary

COG2940
Location:478 → 734

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam11616
Location:39 → 67

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 257

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

cd19218
Location:617 → 736

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
XM_012964797.3 → XP_012820251.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/TrEMBL

A0A6I8SN85, A0A8J0SR10

Related

ENSXETP00000064368.1, ENSXETT00000099506.2

Conserved Domains (2) summary

smart00317
Location:629 → 750

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam11616
Location:54 → 82

EZH2_WD-Binding; WD repeat binding protein EZH2