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eif2b1 eukaryotic translation initiation factor 2B subunit alpha [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 550040, updated on 4-Nov-2024

Summary

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Official Symbol
eif2b1provided by Xenbase
Official Full Name
eukaryotic translation initiation factor 2B subunit alphaprovided by Xenbase
Primary source
Xenbase:XB-GENE-972471
See related
Ensembl:ENSXETG00000005830 AllianceGenome:Xenbase:XB-GENE-972471
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
eif2b; eif-2b; eif2ba; eif-2balpha
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See eif2b1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (160976165..160982458)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (152353257..152359536)

Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101734664 Neighboring gene general transcription factor IIH subunit 3 Neighboring gene DEAD-box helicase 55 Neighboring gene transmembrane p24 trafficking protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
translation initiation factor eIF2B subunit alpha; translation initiation factor eIF-2B subunit alpha
Names
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017286.2 → NP_001017286.1  translation initiation factor eIF2B subunit alpha

    See identical proteins and their annotated locations for NP_001017286.1

    Status: PROVISIONAL

    Source sequence(s)
    CR855697
    UniProtKB/TrEMBL
    A0A6I8R814, Q28D56
    Related
    ENSXETP00000076760.2, ENSXETT00000095980.2
    Conserved Domains (1) summary
    pfam01008
    Location:15 → 289
    IF-2B; Initiation factor 2 subunit family

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    160976165..160982458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012963481.2 → XP_012818935.2  translation initiation factor eIF-2B subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A6I8R814, A0A8J0SPE0
    Conserved Domains (1) summary
    pfam01008
    Location:69 → 344
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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