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TTC22 tetratricopeptide repeat domain 22 [ Homo sapiens (human) ]

Gene ID: 55001, updated on 5-Mar-2024

Summary

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Official Symbol
TTC22provided by HGNC
Official Full Name
tetratricopeptide repeat domain 22provided by HGNC
Primary source
HGNC:HGNC:26067
See related
Ensembl:ENSG00000006555 AllianceGenome:HGNC:26067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Biased expression in esophagus (RPKM 8.5), colon (RPKM 4.0) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
1p32.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54779712..54801323, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54659937..54681544, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55245385..55266996, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55181271-55181772 Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55229956-55230579 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55246797-55247339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55247340-55247881 Neighboring gene uncharacterized LOC124904182 Neighboring gene Sharpr-MPRA regulatory region 10932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55261394-55261933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55261934-55262472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55266799-55267564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55277747-55278246 Neighboring gene ciliary microtubule associated protein 2 Neighboring gene uncharacterized LOC124904183 Neighboring gene MPRA-validated peak246 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55316729-55317230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55317231-55317730 Neighboring gene 24-dehydrocholesterol reductase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55348920-55349489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55352395-55352896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Revealing PACMA 31 as a new chemical type TrxR inhibitor to promote cancer cell apoptosis. Xu Q, et al. Biochim Biophys Acta Mol Cell Res, 2022 Oct. PMID 35793738
  2. miR663a‑TTC22V1 axis inhibits colon cancer metastasis. Tian W, et al. Oncol Rep, 2019 Mar. PMID 30664167, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20619

General protein information

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Preferred Names
tetratricopeptide repeat protein 22
Names
TPR repeat protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029054.2 RefSeqGene

    Range
    5000..26611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001114108.2 → NP_001107580.1  tetratricopeptide repeat protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001107580.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC096536, AL139244
    Consensus CDS
    CCDS44152.1
    UniProtKB/Swiss-Prot
    Q5TAA0, Q9NWT4
    Related
    ENSP00000360323.4, ENST00000371276.9
    Conserved Domains (1) summary
    sd00006
    Location:65 → 95
    TPR; TPR repeat [structural motif]

  2. NM_017904.4 → NP_060374.2  tetratricopeptide repeat protein 22 isoform 2

    See identical proteins and their annotated locations for NP_060374.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC096536, AL139244
    Consensus CDS
    CCDS598.1
    UniProtKB/Swiss-Prot
    Q5TAA0
    Related
    ENSP00000360321.4, ENST00000371274.8
    Conserved Domains (1) summary
    sd00006
    Location:65 → 95
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    54779712..54801323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541671.3 → XP_011539973.1  tetratricopeptide repeat protein 22 isoform X1

    Conserved Domains (1) summary
    sd00006
    Location:294 → 324
    TPR; TPR repeat [structural motif]

  2. XM_017001582.2 → XP_016857071.1  tetratricopeptide repeat protein 22 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    54659937..54681544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337293.1 → XP_054193268.1  tetratricopeptide repeat protein 22 isoform X1

  2. XM_054337294.1 → XP_054193269.1  tetratricopeptide repeat protein 22 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TAA0.1 GenPept UniProtKB/Swiss-Prot:Q5TAA0

Gene LinkOut

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