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TMEM132A transmembrane protein 132A [ Homo sapiens (human) ]

Gene ID: 54972, updated on 14-Nov-2024

Summary

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Official Symbol
TMEM132Aprovided by HGNC
Official Full Name
transmembrane protein 132Aprovided by HGNC
Primary source
HGNC:HGNC:31092
See related
Ensembl:ENSG00000006118 MIM:617363; AllianceGenome:HGNC:31092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP; HSPA5BP1
Summary
This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 20.0), endometrium (RPKM 7.5) and 12 other tissues See more
Orthologs
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Genomic context

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See TMEM132A in Genome Data Viewer
Location:
11q12.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (60924460..60937159)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (60875611..60888306)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60691932..60704631)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60679869-60680867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60681866-60682864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4785 Neighboring gene TMEM109 divergent transcript Neighboring gene uncharacterized LOC124902676 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:60686309-60687508 Neighboring gene transmembrane protein 109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3380 Neighboring gene solute carrier family 15 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4787 Neighboring gene CD6 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4788 Neighboring gene RNA, U6 small nuclear 933, pseudogene Neighboring gene tRNA-Ala (TGC) 10-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. Lee E, et al. J Cell Biol, 2001 Sep 3. PMID 11524435, Free PMC Article
  2. GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells. Oh-hashi K, et al. FEBS Lett, 2006 Jul 10. PMID 16806201
  3. Cloning and characterization of a novel GRP78-binding protein in the rat brain. Oh-hashi K, et al. J Biol Chem, 2003 Mar 21. PMID 12514190
  4. TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. Sanchez-Pulido L, et al. Bioinformatics, 2018 Mar 1. PMID 29088312, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. describes characterization of the rat protein
    Title: Cloning and characterization of a novel GRP78-binding protein in the rat brain.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 132A (TMEM132A; HSPA5BP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20539, MGC138669, DKFZp547E212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 132A
Names
GRP78-binding protein
HSPA5-binding protein 1
glucose-regulated protein, 78kDa
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) binding protein 1
heat shock 70kDa protein 5 binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017870.4 → NP_060340.2  transmembrane protein 132A isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK000546, AK023577, AL359557, AP003721, BC028106, BC032059
    Consensus CDS
    CCDS7997.1
    UniProtKB/Swiss-Prot
    Q24JP5
    Related
    ENSP00000005286.4, ENST00000005286.8
    Conserved Domains (3) summary
    pfam15705
    Location:50 → 171
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:837 → 904
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:408 → 750
    TMEM132; Transmembrane protein family 132

  2. NM_178031.3 → NP_821174.1  transmembrane protein 132A isoform b precursor

    See identical proteins and their annotated locations for NP_821174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different in-frame splice site in the coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK000546, AL359557, AP003721, BC028106
    Consensus CDS
    CCDS44618.1
    UniProtKB/Swiss-Prot
    Q24JP5, Q69YU7, Q86VZ8, Q86W97, Q9H8K3, Q9HCI9, Q9NWY0
    Related
    ENSP00000405823.2, ENST00000453848.7
    Conserved Domains (3) summary
    pfam15705
    Location:48 → 170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:836 → 901
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:407 → 749
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    60924460..60937159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017951.3 → XP_016873440.1  transmembrane protein 132A isoform X1

  2. XM_017017952.3 → XP_016873441.1  transmembrane protein 132A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    60875611..60888306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369218.1 → XP_054225193.1  transmembrane protein 132A isoform X1

  2. XM_054369219.1 → XP_054225194.1  transmembrane protein 132A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24JP5.1 GenPept UniProtKB/Swiss-Prot:Q24JP5

Gene LinkOut

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