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CT55 cancer/testis antigen 55 [ Homo sapiens (human) ]

Gene ID: 54967, updated on 5-Mar-2024

Summary

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Official Symbol
CT55provided by HGNC
Official Full Name
cancer/testis antigen 55provided by HGNC
Primary source
HGNC:HGNC:26047
See related
Ensembl:ENSG00000169551 MIM:301105; AllianceGenome:HGNC:26047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPGFX7; CXorf48; BJHCC20A
Expression
Restricted expression toward testis (RPKM 1.5) See more
Orthologs
all
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Genomic context

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See CT55 in Genome Data Viewer
Location:
Xq26.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135156536..135171827, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (133482335..133497625, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134290461..134305751, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SMIM10L2B antisense RNA 1 Neighboring gene zinc finger protein 449 pseudogene Neighboring gene uncharacterized LOC124905295 Neighboring gene cancer/testis antigen 55 pseudogene Neighboring gene cancer/testis antigen 55 pseudogene Neighboring gene uncharacterized LOC124905298

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cancer/Testis Antigen 55 is required for cancer cell proliferation and mitochondrial DNA maintenance. Aurrière J, et al. Mitochondrion, 2022 May. PMID 35189384, Free PMC Article
  2. CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients. Matsushita M, et al. Blood Cancer J, 2017 Sep 1. PMID 28862699, Free PMC Article
  3. Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice. Zhang G, et al. Cell Death Differ, 2023 Feb. PMID 36481789, Free PMC Article
  4. Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage. Tomiyoshi G, et al. Cancer Sci, 2008 Apr. PMID 18307534
  5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.
    Title: Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.
  2. the relapse rate of CXorf48-specific CTL-negative patients was 63.6%, compared to 0% in CXorf48-specific CTL-positive patients. These results indicate that CXorf48 could be a promising therapeutic target of LSCs for immunotherapy to obtain durable treatment-free remission in CML patients.
    Title: CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients.
  3. A novel BRCA2-interacting protein, BJ-HCC-20A, which is reported to be a potential cancer-testis antigen, was identified.
    Title: Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spermatogenic failure, X-linked, 7
MedGen: C5829567 OMIM: 301106 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20527

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cancer/testis antigen 55
Names
BRCA2-interacting protein
tumor antigen BJ-HCC-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031705.3 → NP_001026875.1  cancer/testis antigen 55 isoform 1

    See identical proteins and their annotated locations for NP_001026875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer isoform (1).
    Source sequence(s)
    AF520814, AY352211
    Consensus CDS
    CCDS35400.1
    UniProtKB/Swiss-Prot
    Q8WUE5, Q9NWY8
    Related
    ENSP00000276241.6, ENST00000276241.11
    Conserved Domains (1) summary
    pfam14444
    Location:182 → 233
    S1-like; S1-like

  2. NM_017863.2 → NP_060333.1  cancer/testis antigen 55 isoform 2

    See identical proteins and their annotated locations for NP_060333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
    Source sequence(s)
    AY352211
    Consensus CDS
    CCDS14647.1
    UniProtKB/Swiss-Prot
    Q8WUE5
    Related
    ENSP00000343893.2, ENST00000344129.2
    Conserved Domains (1) summary
    pfam14444
    Location:182 → 233
    S1-like; S1-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    135156536..135171827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    133482335..133497625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WUE5.1 GenPept UniProtKB/Swiss-Prot:Q8WUE5

Gene LinkOut

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