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TXNL4B thioredoxin like 4B [ Homo sapiens (human) ]

Gene ID: 54957, updated on 3-Apr-2024

Summary

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Official Symbol
TXNL4Bprovided by HGNC
Official Full Name
thioredoxin like 4Bprovided by HGNC
Primary source
HGNC:HGNC:26041
See related
Ensembl:ENSG00000140830 MIM:617722; AllianceGenome:HGNC:26041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLP; Dim2
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 7.1), testis (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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See TXNL4B in Genome Data Viewer
Location:
16q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (72084857..72094378, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (77901171..77912511, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (72118756..72128277, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene haptoglobin Neighboring gene haptoglobin-related protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:72132901-72133401 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:72141414-72142613 Neighboring gene DEAH-box helicase 38 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:72159455-72159956 Neighboring gene NANOG hESC enhancer GRCh37_chr16:72162293-72163093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:72163923-72164424 Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:72171124-72171624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11095 Neighboring gene uncharacterized LOC105371341 Neighboring gene VISTA enhancer hs22 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:72257113-72258312 Neighboring gene uncharacterized LOC124903720 Neighboring gene MYC binding protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High-resolution crystal structure of human Dim2/TXNL4B. Jin T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Mar 1. PMID 23519793, Free PMC Article
  2. Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B. Jin T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Mar 1. PMID 16511018, Free PMC Article
  3. Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2. Simeoni F, et al. Biochemistry, 2005 Sep 13. PMID 16142897
  4. Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells. Schelling P, et al. J Biol Chem, 2004 Jul 30. PMID 15163659
  5. A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. Froguel P, et al. PLoS One, 2012. PMID 22403646, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A crystal structure of TXNL4B was determined at 1.33 A resolution and refined to an Rwork of 0.13 and an Rfree of 0.18 with one native dimer in the asymmetric unit.
    Title: High-resolution crystal structure of human Dim2/TXNL4B.
  2. The human gene coding for the spliceosomal protein thioredoxin-like 4B (TXNL4B) was overexpressed in Escherichia coli and the encoded protein was purified and crystallized.
    Title: Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B.
  3. DLP is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing
    Title: DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression.
  4. crystal structure; in contrast to hDim1, hDim2 forms stable homodimers
    Title: Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.
EBI GWAS Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of thioredoxin-like 4B (TXNL4B) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thioredoxin-like protein 4B
Names
Dim1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142317.2 → NP_001135789.1  thioredoxin-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_001135789.1

    Status: VALIDATED

    Source sequence(s)
    AC009087, BC009646, DA499499
    Consensus CDS
    CCDS10906.1
    UniProtKB/Swiss-Prot
    D3DWS6, Q9NX01
    UniProtKB/TrEMBL
    Q53GP2
    Related
    ENSP00000408130.1, ENST00000423037.5
    Conserved Domains (1) summary
    cd02986
    Location:10 → 123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

  2. NM_001142318.2 → NP_001135790.1  thioredoxin-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_001135790.1

    Status: VALIDATED

    Source sequence(s)
    AC009087, BC009646, CD517462
    Consensus CDS
    CCDS10906.1
    UniProtKB/Swiss-Prot
    D3DWS6, Q9NX01
    UniProtKB/TrEMBL
    Q53GP2
    Related
    ENSP00000392310.2, ENST00000426362.6
    Conserved Domains (1) summary
    cd02986
    Location:10 → 123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

  3. NM_001324354.2 → NP_001311283.1  thioredoxin-like protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009087
    UniProtKB/TrEMBL
    H3BUL8
    Related
    ENSP00000457699.1, ENST00000569767.1
    Conserved Domains (1) summary
    cl00388
    Location:10 → 95
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  4. NM_001324355.2 → NP_001311284.1  thioredoxin-like protein 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009087, BM849401

  5. NM_017853.3 → NP_060323.1  thioredoxin-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_060323.1

    Status: VALIDATED

    Source sequence(s)
    AC009087, BC009646, BP355646
    Consensus CDS
    CCDS10906.1
    UniProtKB/Swiss-Prot
    D3DWS6, Q9NX01
    UniProtKB/TrEMBL
    Q53GP2
    Related
    ENSP00000268483.3, ENST00000268483.8
    Conserved Domains (1) summary
    cd02986
    Location:10 → 123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    72084857..72094378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    77901171..77912511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380589.1 → XP_054236564.1  thioredoxin-like protein 4B isoform X1

    UniProtKB/Swiss-Prot
    D3DWS6, Q9NX01
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NX01.1 GenPept UniProtKB/Swiss-Prot:Q9NX01

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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