BCOR BCL6 corepressor [Homo sapiens (human)] - Gene

Summary

Official Symbol: BCORprovided by HGNC
Official Full Name: BCL6 corepressorprovided by HGNC
Primary source: HGNC:HGNC:20893
See related: Ensembl:ENSG00000183337 MIM:300485; AllianceGenome:HGNC:20893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAA2; ANOP2; MCOPS2
Summary: The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]
Expression: Ubiquitous expression in thyroid (RPKM 8.0), lymph node (RPKM 7.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp11.4

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (40051246..40177329, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (39452491..39578567, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (39910499..40036582, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evaluation of Lineage/Site-specific Nuclear Immunohistochemical Markers SATB2, Cyclin D1, SALL4, and BCOR in High-grade Endometrial Carcinomas.
Title: Evaluation of Lineage/Site-specific Nuclear Immunohistochemical Markers SATB2, Cyclin D1, SALL4, and BCOR in High-grade Endometrial Carcinomas.
Clinical relevance of BCOR internal tandem duplication and TP53 aberration in clear cell sarcoma of the kidney.
Title: Clinical relevance of BCOR internal tandem duplication and TP53 aberration in clear cell sarcoma of the kidney.
A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
Title: A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl).
Pediatric BCOR-Altered Tumors From Soft Tissue/Kidney Display Specific DNA Methylation Profiles.
Title: Pediatric BCOR-Altered Tumors From Soft Tissue/Kidney Display Specific DNA Methylation Profiles.
X-linked BCOR variants identified in Chinese Han patients with congenital heart disease.
Title: X-linked BCOR variants identified in Chinese Han patients with congenital heart disease.
BCOR variants are associated with X-linked recessive partial epilepsy.
Title: BCOR variants are associated with X-linked recessive partial epilepsy.
CNS tumor with BCOR internal tandem duplication: Clinicopathologic, molecular characteristics and prognosis factors.
Title: CNS tumor with BCOR internal tandem duplication: Clinicopathologic, molecular characteristics and prognosis factors.
Paediatric BCOR-associated sarcomas with a novel long spliced internal tandem duplication of BCOR exon 15.
Title: Paediatric BCOR-associated sarcomas with a novel long spliced internal tandem duplication of BCOR exon 15.
Endometrial Stromal Sarcomas With BCOR Internal Tandem Duplication and Variant BCOR/BCORL1 Rearrangements Resemble High-grade Endometrial Stromal Sarcomas With Recurrent CDK4 Pathway Alterations and MDM2 Amplifications.
Title: Endometrial Stromal Sarcomas With BCOR Internal Tandem Duplication and Variant BCOR/BCORL1 Rearrangements Resemble High-grade Endometrial Stromal Sarcomas With Recurrent CDK4 Pathway Alterations and MDM2 Amplifications.
Soft Tissue and Visceral Organ Sarcomas With BCOR Alterations.
Title: Soft Tissue and Visceral Organ Sarcomas With BCOR Alterations.

Submit: New GeneRIF Correction See all GeneRIFs (96)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Microphthalmia, syndromic 1 MedGen: C0796016 OMIM: 309800 GeneReviews: Not available	Compare labs
Oculofaciocardiodental syndrome MedGen: C1846265 OMIM: 300166 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2012-10-04) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2012-10-04) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXS7568 (e-PCR)
- UniSTS:43034

DXS228 (e-PCR)
- UniSTS:99110

RH101975 (e-PCR)
- UniSTS:96309

SHGC-147935 (e-PCR)
- UniSTS:172902

RH91894 (e-PCR)
- UniSTS:88168

DXS992 (e-PCR)
- UniSTS:3724

SHGC-56557 (e-PCR)
- UniSTS:2473

Bcor (e-PCR), detects polymorphism
- UniSTS:502718

Bcor (e-PCR), detects polymorphism
- UniSTS:502720

G66543 (e-PCR)
- UniSTS:230380

Clone Names

FLJ20285, FLJ38041, KIAA1575, MGC71031, MGC131961

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in blastocyst hatching	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tooth mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of axis polarity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of BCOR complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BCL-6 corepressor

Names: BCL-6 coreceptor; BCL-6 interacting corepressor; BCL6 interacting corepressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008880.1 RefSeqGene

Range

5001..131084

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_627

mRNA and Protein(s)

NM_001123383.1 → NP_001116855.1 BCL-6 corepressor isoform a

See identical proteins and their annotated locations for NP_001116855.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site compared to variant 5. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c. Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AC092198, AK056538, BC114220

Consensus CDS

CCDS14250.1

UniProtKB/TrEMBL

H7C2V9

Related

ENSP00000345923.4, ENST00000342274.8

Conserved Domains (5) summary

cd00204
Location:1423 → 1531

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1598 → 1712

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1433 → 1524

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1168 → 1380

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1429 → 1460

ANK; ANK repeat [structural motif]
NM_001123384.2 → NP_001116856.1 BCL-6 corepressor isoform b

See identical proteins and their annotated locations for NP_001116856.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks two alternate in-frame segments compared to variant 5. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.

Source sequence(s)

AC092198, BC114220

Consensus CDS

CCDS48092.1

UniProtKB/TrEMBL

H7C2V9

Related

ENSP00000367716.4, ENST00000378455.8

Conserved Domains (5) summary

cd00204
Location:1405 → 1513

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1580 → 1694

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1415 → 1506

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1150 → 1362

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1411 → 1442

ANK; ANK repeat [structural motif]
NM_001123385.2 → NP_001116857.1 BCL-6 corepressor isoform c

See identical proteins and their annotated locations for NP_001116857.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (c).

Source sequence(s)

AC092198, AK056538, AL591802, AL698729, AY316592, BC114220

Consensus CDS

CCDS48093.1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

UniProtKB/TrEMBL

H7C2V9

Related

ENSP00000367705.4, ENST00000378444.9

Conserved Domains (5) summary

cd00204
Location:1457 → 1565

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1632 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1202 → 1414

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]
NM_017745.6 → NP_060215.4 BCL-6 corepressor isoform a

See identical proteins and their annotated locations for NP_060215.4

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 5. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c. Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AC092198, AK056538, AL591802, AL698729, BC114220

Consensus CDS

CCDS14250.1

UniProtKB/TrEMBL

H7C2V9

Related

ENSP00000380512.3, ENST00000397354.7

Conserved Domains (5) summary

cd00204
Location:1423 → 1531

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1598 → 1712

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1433 → 1524

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1168 → 1380

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1429 → 1460

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

40051246..40177329 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047442202.1 → XP_047298158.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_005272616.2 → XP_005272673.1 BCL-6 corepressor isoform X1

See identical proteins and their annotated locations for XP_005272673.1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

UniProtKB/TrEMBL

H7C2V9

Related

ENSP00000499892.2, ENST00000672922.2

Conserved Domains (5) summary

cd00204
Location:1457 → 1565

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1632 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1202 → 1414

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]
XM_047442223.1 → XP_047298179.1 BCL-6 corepressor isoform X4
XM_047442205.1 → XP_047298161.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_047442213.1 → XP_047298169.1 BCL-6 corepressor isoform X3
XM_011543931.3 → XP_011542233.1 BCL-6 corepressor isoform X1

See identical proteins and their annotated locations for XP_011542233.1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

UniProtKB/TrEMBL

H7C2V9

Conserved Domains (5) summary

cd00204
Location:1457 → 1565

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1632 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1202 → 1414

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]
XM_047442219.1 → XP_047298175.1 BCL-6 corepressor isoform X4
XM_047442201.1 → XP_047298157.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_047442210.1 → XP_047298166.1 BCL-6 corepressor isoform X3
XM_011543930.2 → XP_011542232.1 BCL-6 corepressor isoform X1

See identical proteins and their annotated locations for XP_011542232.1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

UniProtKB/TrEMBL

H7C2V9

Conserved Domains (5) summary

cd00204
Location:1457 → 1565

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1632 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1202 → 1414

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]
XM_047442221.1 → XP_047298177.1 BCL-6 corepressor isoform X4
XM_047442208.1 → XP_047298164.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_047442211.1 → XP_047298167.1 BCL-6 corepressor isoform X3
XM_011543929.3 → XP_011542231.1 BCL-6 corepressor isoform X1

See identical proteins and their annotated locations for XP_011542231.1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

UniProtKB/TrEMBL

H7C2V9

Conserved Domains (5) summary

cd00204
Location:1457 → 1565

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1632 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1202 → 1414

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]
XM_047442228.1 → XP_047298184.1 BCL-6 corepressor isoform X4
XM_047442197.1 → XP_047298153.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

Related

ENSP00000483217.2, ENST00000615339.2
XM_047442214.1 → XP_047298170.1 BCL-6 corepressor isoform X3
XM_047442216.1 → XP_047298172.1 BCL-6 corepressor isoform X3
XM_047442207.1 → XP_047298163.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_047442224.1 → XP_047298180.1 BCL-6 corepressor isoform X4
XM_047442204.1 → XP_047298160.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_047442198.1 → XP_047298154.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_047442199.1 → XP_047298155.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_047442218.1 → XP_047298174.1 BCL-6 corepressor isoform X3
XM_047442227.1 → XP_047298183.1 BCL-6 corepressor isoform X4
XM_047442196.1 → XP_047298152.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

Related

ENSP00000505507.1, ENST00000680831.1
XM_047442222.1 → XP_047298178.1 BCL-6 corepressor isoform X4
XM_047442209.1 → XP_047298165.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_047442217.1 → XP_047298173.1 BCL-6 corepressor isoform X3
XM_047442220.1 → XP_047298176.1 BCL-6 corepressor isoform X4
XM_047442203.1 → XP_047298159.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231

Related

ENSP00000403823.3, ENST00000427012.3
XM_047442212.1 → XP_047298168.1 BCL-6 corepressor isoform X3

Related

ENSP00000408006.2, ENST00000413905.6
XM_005272618.4 → XP_005272675.1 BCL-6 corepressor isoform X1

See identical proteins and their annotated locations for XP_005272675.1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

UniProtKB/TrEMBL

H7C2V9

Related

ENSP00000384485.3, ENST00000406200.4

Conserved Domains (5) summary

cd00204
Location:1457 → 1565

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1632 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1202 → 1414

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]
XM_005272620.5 → XP_005272677.1 BCL-6 corepressor isoform X4

See identical proteins and their annotated locations for XP_005272677.1

UniProtKB/TrEMBL

H7C2V9

Conserved Domains (5) summary

cd00204
Location:1405 → 1513

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1580 → 1694

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1415 → 1506

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1150 → 1362

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1411 → 1442

ANK; ANK repeat [structural motif]
XM_005272619.5 → XP_005272676.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231, H7C2V9

Conserved Domains (5) summary

cd00204
Location:1439 → 1547

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1614 → 1728

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1449 → 1540

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1184 → 1396

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1445 → 1476

ANK; ANK repeat [structural motif]
XM_017029616.3 → XP_016885105.1 BCL-6 corepressor isoform X5

UniProtKB/TrEMBL

H7BZ37, H7C2V9

Related

ENSP00000387552.2, ENST00000442018.6
XM_017029615.2 → XP_016885104.1 BCL-6 corepressor isoform X3

UniProtKB/TrEMBL

H7C2V9

Related

ENSP00000500446.1, ENST00000673391.1

Conserved Domains (5) summary

cd00204
Location:1423 → 1531

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1598 → 1712

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1433 → 1524

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1168 → 1380

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1429 → 1460

ANK; ANK repeat [structural motif]
XM_006724536.4 → XP_006724599.1 BCL-6 corepressor isoform X1

See identical proteins and their annotated locations for XP_006724599.1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

UniProtKB/TrEMBL

H7C2V9

Conserved Domains (5) summary

cd00204
Location:1457 → 1565

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14261
Location:1632 → 1746

PUFD; PCGF Ub-like fold discriminator of BCOR

pfam12796
Location:1467 → 1558

Ank_2; Ankyrin repeats (3 copies)

pfam15808
Location:1202 → 1414

BCOR; BCL-6 co-repressor, non-ankyrin-repeat region

sd00045
Location:1463 → 1494

ANK; ANK repeat [structural motif]
XM_047442225.1 → XP_047298181.1 BCL-6 corepressor isoform X4
XM_047442206.1 → XP_047298162.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_047442226.1 → XP_047298182.1 BCL-6 corepressor isoform X4
XM_047442215.1 → XP_047298171.1 BCL-6 corepressor isoform X3
XM_047442200.1 → XP_047298156.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

Related

ENSP00000505761.1, ENST00000679513.1

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

39452491..39578567 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054327306.1 → XP_054183281.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327293.1 → XP_054183268.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327314.1 → XP_054183289.1 BCL-6 corepressor isoform X3
XM_054327295.1 → XP_054183270.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327309.1 → XP_054183284.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327326.1 → XP_054183301.1 BCL-6 corepressor isoform X4
XM_054327331.1 → XP_054183306.1 BCL-6 corepressor isoform X4
XM_054327321.1 → XP_054183296.1 BCL-6 corepressor isoform X3
XM_054327301.1 → XP_054183276.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327320.1 → XP_054183295.1 BCL-6 corepressor isoform X3
XM_054327333.1 → XP_054183308.1 BCL-6 corepressor isoform X4
XM_054327312.1 → XP_054183287.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327294.1 → XP_054183269.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327305.1 → XP_054183280.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327334.1 → XP_054183309.1 BCL-6 corepressor isoform X4
XM_054327297.1 → XP_054183272.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327315.1 → XP_054183290.1 BCL-6 corepressor isoform X3
XM_054327317.1 → XP_054183292.1 BCL-6 corepressor isoform X3
XM_054327311.1 → XP_054183286.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327327.1 → XP_054183302.1 BCL-6 corepressor isoform X4
XM_054327308.1 → XP_054183283.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327299.1 → XP_054183274.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327300.1 → XP_054183275.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327319.1 → XP_054183294.1 BCL-6 corepressor isoform X3
XM_054327330.1 → XP_054183305.1 BCL-6 corepressor isoform X4
XM_054327296.1 → XP_054183271.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327325.1 → XP_054183300.1 BCL-6 corepressor isoform X4
XM_054327313.1 → XP_054183288.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327318.1 → XP_054183293.1 BCL-6 corepressor isoform X3
XM_054327322.1 → XP_054183297.1 BCL-6 corepressor isoform X3
XM_054327332.1 → XP_054183307.1 BCL-6 corepressor isoform X4
XM_054327303.1 → XP_054183278.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327307.1 → XP_054183282.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327324.1 → XP_054183299.1 BCL-6 corepressor isoform X4
XM_054327304.1 → XP_054183279.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327335.1 → XP_054183310.1 BCL-6 corepressor isoform X5

UniProtKB/TrEMBL

H7BZ37
XM_054327323.1 → XP_054183298.1 BCL-6 corepressor isoform X3
XM_054327298.1 → XP_054183273.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2
XM_054327328.1 → XP_054183303.1 BCL-6 corepressor isoform X4
XM_054327310.1 → XP_054183285.1 BCL-6 corepressor isoform X2

UniProtKB/TrEMBL

H7C231
XM_054327316.1 → XP_054183291.1 BCL-6 corepressor isoform X3
XM_054327329.1 → XP_054183304.1 BCL-6 corepressor isoform X4
XM_054327302.1 → XP_054183277.1 BCL-6 corepressor isoform X1

UniProtKB/Swiss-Prot

D3DWB3, D3DWB4, Q29RF6, Q6P4B6, Q6W2J9, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001130139.1: Suppressed sequence

Description

NM_001130139.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
NM_020926.2: Suppressed sequence

Description

NM_020926.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.