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PAQR5 progestin and adipoQ receptor family member 5 [ Homo sapiens (human) ]

Gene ID: 54852, updated on 5-Mar-2024

Summary

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Official Symbol
PAQR5provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 5provided by HGNC
Primary source
HGNC:HGNC:29645
See related
Ensembl:ENSG00000137819 MIM:607781; AllianceGenome:HGNC:29645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPRG
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in oogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 13.9), adrenal (RPKM 5.4) and 9 other tissues See more
Orthologs
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Genomic context

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Location:
15q23
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69298912..69407780)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (67121429..67229857)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69591251..69700119)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucuronic acid epimerase Neighboring gene RNA, 7SL, cytoplasmic 438, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:69564446-69565003 Neighboring gene PAQR5 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:69597275-69598474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69610145-69610644 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69615648-69615826 Neighboring gene small nucleolar RNA SNORA77 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69634596-69635096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69635097-69635597 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69673828-69674009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69680714-69681358 Neighboring gene KIF23 and PAQR5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6599 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene kinesin family member 23 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9656 Neighboring gene long intergenic non-protein coding RNA 2896 Neighboring gene ribosomal protein lateral stalk subunit P1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. Charles NJ, et al. Horm Cancer, 2010 Aug. PMID 21761364, Free PMC Article
  2. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Zhu Y, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12574519, Free PMC Article
  3. Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. Smith JL, et al. Steroids, 2008 Oct. PMID 18603275, Free PMC Article
  4. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Zhu Y, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12601167, Free PMC Article
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Wang KS, et al. Schizophr Res, 2010 Dec. PMID 20889312

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
    Title: PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway.
  2. Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRalpha protein expression in a panel of commonly used ovarian cancer cell lines.
    Title: Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.
  3. Heterologous expression of MPRG in yeast confirms its ability to function as a membrane progesterone receptor.
    Title: Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20190

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane progestin receptor gamma
Names
mPR gamma
membrane progesterone P4 receptor gamma
membrane progesterone receptor gamma
progesterone and adipoQ receptor family member 5
progestin and adipoQ receptor family member V

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104554.2 → NP_001098024.1  membrane progestin receptor gamma

    See identical proteins and their annotated locations for NP_001098024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC027237, AW779994, AY424283, BC039234
    Consensus CDS
    CCDS10232.1
    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6
    Related
    ENSP00000453526.1, ENST00000561153.5
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 269
    HlyIII; Haemolysin-III related

  2. NM_017705.4 → NP_060175.3  membrane progestin receptor gamma

    See identical proteins and their annotated locations for NP_060175.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC026992, AC027237, AW779994, BC039234, BE747523
    Consensus CDS
    CCDS10232.1
    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6
    Related
    ENSP00000378803.2, ENST00000395407.7
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 269
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    69298912..69407780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432749.1 → XP_047288705.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  2. XM_047432747.1 → XP_047288703.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  3. XM_047432748.1 → XP_047288704.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  4. XM_047432746.1 → XP_047288702.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  5. XM_017022360.2 → XP_016877849.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 269
    HlyIII; Haemolysin-III related

  6. XM_047432744.1 → XP_047288700.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  7. XM_017022362.2 → XP_016877851.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 269
    HlyIII; Haemolysin-III related

  8. XM_047432753.1 → XP_047288709.1  membrane progestin receptor gamma isoform X6

  9. XM_047432743.1 → XP_047288699.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  10. XM_047432751.1 → XP_047288707.1  membrane progestin receptor gamma isoform X4

  11. XM_011521720.3 → XP_011520022.1  membrane progestin receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_011520022.1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 269
    HlyIII; Haemolysin-III related

  12. XM_047432750.1 → XP_047288706.1  membrane progestin receptor gamma isoform X4

  13. XM_011521727.3 → XP_011520029.1  membrane progestin receptor gamma isoform X6

    Conserved Domains (1) summary
    cl03831
    Location:43 → 204
    HlyIII; Haemolysin-III related

  14. XM_011521725.3 → XP_011520027.1  membrane progestin receptor gamma isoform X4

    Conserved Domains (1) summary
    cl03831
    Location:68 → 158
    HlyIII; Haemolysin-III related

  15. XM_047432745.1 → XP_047288701.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  16. XM_024449966.2 → XP_024305734.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6
    Conserved Domains (1) summary
    pfam03006
    Location:43 → 269
    HlyIII; Haemolysin-III related

  17. XM_005254495.5 → XP_005254552.1  membrane progestin receptor gamma isoform X2

    See identical proteins and their annotated locations for XP_005254552.1

    Conserved Domains (1) summary
    pfam03006
    Location:29 → 255
    HlyIII; Haemolysin-III related

  18. XM_047432752.1 → XP_047288708.1  membrane progestin receptor gamma isoform X5

  19. XM_024449967.2 → XP_024305735.1  membrane progestin receptor gamma isoform X3

    Conserved Domains (1) summary
    cl03831
    Location:112 → 202
    HlyIII; Haemolysin-III related

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    67121429..67229857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378282.1 → XP_054234257.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  2. XM_054378280.1 → XP_054234255.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  3. XM_054378281.1 → XP_054234256.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  4. XM_054378279.1 → XP_054234254.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  5. XM_054378270.1 → XP_054234245.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  6. XM_054378275.1 → XP_054234250.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  7. XM_054378271.1 → XP_054234246.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  8. XM_054378290.1 → XP_054234265.1  membrane progestin receptor gamma isoform X6

  9. XM_054378274.1 → XP_054234249.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  10. XM_054378287.1 → XP_054234262.1  membrane progestin receptor gamma isoform X4

  11. XM_054378273.1 → XP_054234248.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  12. XM_054378276.1 → XP_054234251.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  13. XM_054378272.1 → XP_054234247.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  14. XM_054378286.1 → XP_054234261.1  membrane progestin receptor gamma isoform X4

  15. XM_054378289.1 → XP_054234264.1  membrane progestin receptor gamma isoform X6

  16. XM_054378285.1 → XP_054234260.1  membrane progestin receptor gamma isoform X4

  17. XM_054378278.1 → XP_054234253.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  18. XM_054378277.1 → XP_054234252.1  membrane progestin receptor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q8IXU2, Q9NXK6

  19. XM_054378283.1 → XP_054234258.1  membrane progestin receptor gamma isoform X2

  20. XM_054378288.1 → XP_054234263.1  membrane progestin receptor gamma isoform X5

  21. XM_054378284.1 → XP_054234259.1  membrane progestin receptor gamma isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NXK6.2 GenPept UniProtKB/Swiss-Prot:Q9NXK6

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