cav1 caveolin 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: cav1provided by Xenbase
Official Full Name: caveolin 1provided by Xenbase
Primary source: Xenbase:XB-GENE-490008
See related: Ensembl:ENSXETG00000011572 AllianceGenome:Xenbase:XB-GENE-490008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: cav; cgl3; Cav-1; bscl3; vip21; cav1-a; cav1-b; mstp085; caveolin-1
Summary: Predicted to enable beta-catenin binding activity. Predicted to act upstream of or within several processes, including cardiac muscle cell proliferation; regionalization; and regulation of defense response. Predicted to be located in Golgi membrane and caveola. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); lipodystrophy (multiple); primary open angle glaucoma; primary pulmonary hypertension; and systemic scleroderma (multiple). Orthologous to human CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	3	NC_030679.2 (68065745..68089468)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	3	NC_030679.1 (58500800..58525113)

Chromosome 3 - NC_030679.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation.
Title: Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within caveola assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromast development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within notochord cell vacuolation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: caveolin-1

Names: caveolin 1, caveolae protein, 22kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015750.1 → NP_001015750.1 caveolin-1

See identical proteins and their annotated locations for NP_001015750.1

Status: PROVISIONAL

Source sequence(s)

BC089686

UniProtKB/TrEMBL

F7C9K9, Q2QLF5, Q5EBF9

Related

ENSXETP00000054421.2, ENSXETT00000054421.4

Conserved Domains (1) summary

pfam01146
Location:47 → 177

Caveolin

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

68065745..68089468

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001130439.1: Suppressed sequence

Description

NM_001130439.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.