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alg8 ALG8, alpha-1,3-glucosyltransferase [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 548388, updated on 4-Nov-2024

Summary

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Official Symbol
alg8provided by Xenbase
Official Full Name
ALG8, alpha-1,3-glucosyltransferaseprovided by Xenbase
Primary source
Xenbase:XB-GENE-967047
See related
Ensembl:ENSXETG00000010450 AllianceGenome:Xenbase:XB-GENE-967047
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to act upstream of or within protein glycosylation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ih and polycystic liver disease 3. Orthologous to human ALG8 (ALG8 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See alg8 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (168940467..168950659, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (165610597..165620841, complement)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 4 Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene ubiquitin specific peptidase 35 Neighboring gene GRB2 associated binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Names
asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase)
asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog
NP_001076820.1
XP_012812339.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083351.1 → NP_001076820.1  dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

    See identical proteins and their annotated locations for NP_001076820.1

    Status: PROVISIONAL

    Source sequence(s)
    BC135531
    UniProtKB/TrEMBL
    A0A6I8PV94, A4IHH8, Q5FVB1
    Related
    ENSXETP00000059179.3, ENSXETT00000063293.3
    Conserved Domains (1) summary
    pfam03155
    Location:38 → 522
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    168940467..168950659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012956885.3 → XP_012812339.2  probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A8J0SEF4, Q5FVB1
    Conserved Domains (1) summary
    pfam03155
    Location:38 → 465
    Alg6_Alg8; ALG6, ALG8 glycosyltransferase family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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