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zgc:112962 zgc:112962 [ Danio rerio (zebrafish) ]

Gene ID: 548348, updated on 2-Nov-2024

Summary

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Official Symbol
zgc:112962provided by ZNC
Official Full Name
zgc:112962provided by ZNC
Primary source
ZFIN:ZDB-GENE-050410-15
See related
Ensembl:ENSDARG00000069102 AllianceGenome:ZFIN:ZDB-GENE-050410-15
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb82d02; wu:fb82d02
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in membrane organization. Predicted to be located in endomembrane system and nucleus. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Y. Orthologous to several human genes including TOR1AIP2 (torsin 1A interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See zgc:112962 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (21052473..21071760, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (21020388..21039848, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108179096 Neighboring gene si:dkeyp-82a1.6 Neighboring gene aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2 Neighboring gene aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. Postlethwait JH, et al. bioRxiv, 2020 Sep 2. PMID 32908984, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC173689

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC548348

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017552.3 → NP_001017552.2  uncharacterized protein LOC548348 isoform 2

    Status: PREDICTED

    Source sequence(s)
    BX664618
    UniProtKB/TrEMBL
    A0A8M1N586, F6NX99
    Related
    ENSDARP00000091061.3, ENSDART00000100288.4

  2. NM_001105143.2 → NP_001098613.2  uncharacterized protein LOC548348 isoform 1

    Status: PREDICTED

    Source sequence(s)
    BX664618
    UniProtKB/TrEMBL
    A0A2R8QDI5, A0A8M2BEC0
    Related
    ENSDARP00000151017.1, ENSDART00000184184.1
    Conserved Domains (2) summary
    pfam05609
    Location:477 → 728
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    cl26761
    Location:7 → 360
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    21052473..21071760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222951.1 → XP_068079052.1  uncharacterized protein LOC548348 isoform X2

  2. XM_009303894.4 → XP_009302169.1  uncharacterized protein LOC548348 isoform X1

    See identical proteins and their annotated locations for XP_009302169.1

    UniProtKB/TrEMBL
    A0A2R8QDI5, A0A8M2BEC0
    Conserved Domains (2) summary
    pfam05609
    Location:477 → 728
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    cl26761
    Location:7 → 360
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  3. XM_021478252.2 → XP_021333927.1  uncharacterized protein LOC548348 isoform X1

    UniProtKB/TrEMBL
    A0A2R8QDI5, A0A8M2BEC0
    Conserved Domains (2) summary
    pfam05609
    Location:477 → 728
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)
    cl26761
    Location:7 → 360
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  4. XM_068222950.1 → XP_068079051.1  uncharacterized protein LOC548348 isoform X2

  5. XM_009303896.4 → XP_009302171.1  uncharacterized protein LOC548348 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B4U5
    Related
    ENSDARP00000100558.2, ENSDART00000111600.4
    Conserved Domains (1) summary
    pfam05609
    Location:470 → 721
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394720.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    104595..114262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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